Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma

Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma

Autor Ashour, Abdussalam Ali Ramadan Autor UNIFESP Google Scholar
Magalhaes, P. P. Google Scholar
Mendes, E. N. Google Scholar
Collares, G. B. Google Scholar
Gusmao, V. R. de Google Scholar
Queiroz, DMM Google Scholar
Nogueira, AMMF Google Scholar
Rocha, G. A. Google Scholar
Oliveira, C. A. de Google Scholar
Instituição Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Itauna
Resumo This PCR-based analysis is the first molecular epidemiological study in Brazil testing Helicobacter pylori cagA and vacA distribution in adults with gastric complaints, that includes a large number of carcinoma patients. Multiple-strain infection was identified in 11/13.4% patients. vacA sl-ml and cagA(+) genotypes were the most common in patients with a non-mixed infection. All vacA s1 strains were s1b, so subtyping s1 strains was not useful. vacA s1b-m1 and cagA(+) strains were associated with higher prevalence of peptic ulcer and gastric carcinoma than vacA s2-m2 and cagA(-) ones. in conclusion, cagA and vacA genotyping may have clinical relevance in Brazil. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Palavra-chave vacA
cagA
bacterial genetic diversity
Helicobacter pylori
Idioma Inglês
Data de publicação 2002-07-12
Publicado em Fems Immunology and Medical Microbiology. Amsterdam: Elsevier B.V., v. 33, n. 3, p. 173-178, 2002.
ISSN 0928-8244 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 173-178
Fonte http://dx.doi.org/10.1111/j.1574-695X.2002.tb00588.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000176884500004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26929

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