Angiotensin actions on the isolated rat uterus during the estrous cycle: Influence of resting membrane potential and uterine morphology

Angiotensin actions on the isolated rat uterus during the estrous cycle: Influence of resting membrane potential and uterine morphology

Autor Accorsi-Mendonca, D. Google Scholar
Correa, FMA Google Scholar
Anselmo-Franci, J. A. Google Scholar
Paiva, T. B. Google Scholar
Oliveira, A. M. de Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The involvement of AT(1) and AT(2) receptor subtypes in the response of the isolated rat uterus to angiotensin 11 (AngII) was studied throughout the estrous cycle. the AngII potency varied during the different estrous cycle phases, as indicated by significantly different pD(2) values. No significant differences were observed in AngII metabolism among different estrous phases. Morphological analysis indicated that external and internal myometrium layers were thicker during estrus. in addition, the highest resting membrane potential was also observed during this phase, when compared with the proestrus and diestrus phases. the AngII-induced uterine contractions were blocked by losartan. Different losartan pD(2) values were observed. PD123319 had no effect on the contractile response to AngII. the results also indicate that estrous cycle-dependent changes in AngII potency are correlated with uterine morphological and/or membrane potential changes. Copyright (C) 2002 S. Karger AG, Basel.
Palavra-chave uterus
angiotensin II
estrous cycle
losartan
AT(1)/AT(2) receptor subtypes
membrane resting potential
Idioma Inglês
Data de publicação 2002-07-01
Publicado em Pharmacology. Basel: Karger, v. 65, n. 3, p. 162-169, 2002.
ISSN 0031-7012 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 162-169
Fonte http://dx.doi.org/10.1159/000058043
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000176413800007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26926

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