Cardiovascular responses to sciatic nerve stimulation are blocked by paratrigeminal nucleus lesion

Cardiovascular responses to sciatic nerve stimulation are blocked by paratrigeminal nucleus lesion

Autor Yu, Y. G. Google Scholar
Caous, C. A. Google Scholar
Balan, A. C. Google Scholar
Rae, G. A. Google Scholar
Lindsey, C. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Santa Catarina (UFSC)
Resumo The paratrigeminal nucleus (Pa5) receives primary sensory inputs from the vagus, glossopharyngeal, and trigeminal nerves and has efferent projections to the nucleus of the solitary tract (NTS), rostroventrolateral reticular nucleus (RVL), as well as to the nucleus ambiguus (Amb), lateral reticular (LRt), parabrachial (PB) and ventral posteromedial thalamic (VPM) nuclei. suggesting that it may play a significant role in cardiovascular responses to nociceptive stimuli. the aim of the present study was to evaluate the effects of unilateral lesions of the Pas on cardiovascular alterations induced by afferent somatic sensory nerve stimulation (SNS), also known as the somatosympathetic reflex (SSR). Cardiovascular responses were recorded in rats following either sham operation or unilateral lesions of the Pas with ibotenic acid. Mean arterial blood pressure (MAP) increased after SNS, which in sham-lesioned animals raised from 95 +/- 4 to 115 +/- 2 mmHg. Ipsilateral Pas lesion did not significantly reduce the pressor response to SNS (from 91 +/- 7 to 107 +/- 4 mmHg increase of baseline MAP). On the other hand, contralateral Pa5 lesion significantly reduced the response to SNS (from 99 +/- 5 to 104 +/- 2 mmHg). Sciatic nerve stimulation did not alter heart rate (HR) neither did ipsi- or contralateral Pas lesion HR baseline response level. These findings support a crucial role for the Pas in cardiovascular regulation, by relaying SSR input evoked by peripheral nerve stimulation. (C) 2002 Elsevier Science B.V. All rights reserved.
Assunto cardiovascular reflexes
nociceptive stimulation
arterial blood pressure
heart rate
somatic pressor reflex
Idioma Inglês
Data 2002-06-28
Publicado em Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 98, n. 1-2, p. 70-74, 2002.
ISSN 1566-0702 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 70-74
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000176882800017

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