One-trial tolerance to the effects of chlordiazepoxide in the elevated plus-maze is not due to acquisition of a phobic avoidance of open arms during initial exposure

One-trial tolerance to the effects of chlordiazepoxide in the elevated plus-maze is not due to acquisition of a phobic avoidance of open arms during initial exposure

Author Frussa-Filho, R. Google Scholar
Ribeiro, R. D. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A single exposure to the elevated plus-maze (EPM) test of anxiety reduces or abolishes the anxiolytic-like efficacy of benzodiazepines. This phenomenon called one-trial tolerance has been suggested to represent the acquisition of a phobic-like response to the open arms during trial 1. the present study was designed to examine the effects of chlordiazepoxide (5 mg/kg, ip) on the behaviour of rats in a conventional EPM apparatus after previous exposure to a four-open-arm EPM, a four-enclosed arm EPM or a conventional EPM, as well as in naive rats. Chlordiazepoxide had clear-cut anxiolytic-like effects (increased percentage of time spent on the open arms) in a traditional EPM in naive rats and in animals previously exposed to a four-open-arm EPM. However, it was ineffective in rats previously exposed to a traditional or a four-closed-arm EPM. Thus, the phenomenon of one-trial tolerance does not depend upon initial open-arm experience. (C) 2002 Elsevier Science Inc. All rights reserved.
Keywords chlordiazepoxide
elevated plus-maze
tolerance
anxiety
phobia
Language English
Date 2002-06-21
Published in Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 71, n. 5, p. 519-525, 2002.
ISSN 0024-3205 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 519-525
Origin http://dx.doi.org/10.1016/S0024-3205(02)01709-5
Access rights Closed access
Type Article
Web of Science ID WOS:000176678700004
URI http://repositorio.unifesp.br/handle/11600/26898

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