Effects of melatonin on orofacial movements in rats

Effects of melatonin on orofacial movements in rats

Author Abilio, V. C. Google Scholar
Vera, JAR Google Scholar
Ferreira, LSM Google Scholar
Duarte, CRM Google Scholar
Carvalho, R. C. Google Scholar
Grassl, C. Google Scholar
Martins, C. R. Google Scholar
Torres-Leite, D. Google Scholar
Bignotto, M. Google Scholar
Tufik, S. Google Scholar
Ribeiro, R. D. Google Scholar
Frussa, R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Rationale: While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidative stress induced by both age and reserpine treatment. Objectives: We intended to determine the preventative effects of exogenous melatonin (one of the most important endogenous antioxidants) as well as suppression of endogenous melatonin via continuous exposure to light on reserpine- or age-induced OM in rats. Methods: Adult (4 months of age) male Wistar rats were repeatedly treated with saline or melatonin (5 mg/kg, IP) and saline or reserpine and kept under a 12-h light/dark cycle for quantification of reserpine-induced OM as well as oxidative stress (via quantification of lipid peroxidation). To verify the effects of endogenous melatonin suppression on reserpine-induced OM, adult rats were repeatedly treated with saline or reserpine and continuously exposed to light. To verify the effects of exogenous melatonin on age-induced OM older (20 months of age) rats were long-term treated with saline or melatonin and kept under a 12-h light/dark cycle. Results: Melatonin attenuated both reserpine- and age-induced OM. Reserpine enhanced striatal lipid peroxidation, that was prevented by melatonin co-administration. Continuous exposure to light increased spontaneous as well as reserpine-induced OM, indicating that endogenous melatonin may be involved in this movement disorder. Conclusions: We suggested that melatonin attenuates both reserpine- and age-induced OM in rats.
Keywords melatonin
orofacial movement
tardive dyskinesia
oxidative stress
Language English
Date 2002-06-01
Published in Psychopharmacology. New York: Springer-verlag, v. 161, n. 4, p. 340-347, 2002.
ISSN 0033-3158 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 340-347
Origin http://dx.doi.org/10.1007/s00213-002-1081-7
Access rights Closed access
Type Article
Web of Science ID WOS:000176573300002
URI http://repositorio.unifesp.br/handle/11600/26880

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