Concomitant development of oral dyskinesia and memory deficits in reserpine-treated male and female mice

Concomitant development of oral dyskinesia and memory deficits in reserpine-treated male and female mice

Author Silva, R. H. Google Scholar
Abilio, V. C. Google Scholar
Torres-Leite, D. Google Scholar
Bergamo, M. Google Scholar
Chinen, C. C. Google Scholar
Claro, F. T. Google Scholar
Carvalho, R. D. Google Scholar
Frussa, R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Santo Amaro
Abstract It has been suggested that reserpine-induced oral dyskinesia in rats may provide a new animal model of tardive dyskinesia. Both cognitive deficits and gender have been associated with the development of tardive dyskinesia. the aim of the present study was to investigate the effects of reserpine administration on the development of orofacial dyskinesia and on plus-maze discriminative avoidance task (DAT-an animal model of associative learning) in male and female mice. Male and female mice received 1.0 mg/kg reserpine or saline subcutaneously on day 1. On days 3, 6 and 8, the frequency of vacuous chewing movements (VCM) was quantified. On day 6, the DAT conditioning was performed, in a modified elevated plus-maze. in one of the enclosed arms, the animals received aversive stimulation (light and noise). On day 8, a test session was performed and the time spent by the animals in each of the enclosed arms was recorded. Our results showed that reserpine-treated male and female mice presented significantly higher VCM when compared with respective control groups in all observation days. On day 6, reserpine-treated female mice presented significantly higher VCM when compared with male mice injected with this drug. the DAT test performed on day 8 showed that the time spent in the aversive arm by saline-treated mice was significantly lower than the time spent in the non-aversive arm. This difference was not observed for reserpine-treated mice. Our results demonstrate the development of reserpine-induced oral dyskinesia in both male and female mice. While this oral dyskinesia is accompanied by a cognitive deficit in both genders, female mice tended to have more severe oral dyskinesia. It is suggested that reserpine-induced oral dyskinesia may provide a quick, simple and efficient mouse model of tardive dyskinesia. (C) 2002 Elsevier Science B.V. All rights reserved.
Keywords tardive dyskinesia
memory
gender
reserpine
behavior
mice
Language English
Date 2002-05-14
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 132, n. 2, p. 171-177, 2002.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 171-177
Origin http://dx.doi.org/10.1016/S0166-4328(01)00409-0
Access rights Closed access
Type Article
Web of Science ID WOS:000176014900005
URI http://repositorio.unifesp.br/handle/11600/26871

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