Interleukin-12 protects mice against disseminated infection caused by Paracoccidioides brasiliensis but enhances pulmonary inflammation

Interleukin-12 protects mice against disseminated infection caused by Paracoccidioides brasiliensis but enhances pulmonary inflammation

Autor Arruda, C. Google Scholar
Franco, M. F. Google Scholar
Kashino, S. S. Google Scholar
Nascimento, FRF Google Scholar
Fazioli, R. D. Google Scholar
Vaz, CAC Google Scholar
Russo, M. Google Scholar
Calich, VLG Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Insat Adolpho Lutz
Resumo Paracoccidioides brasiliensis is a facultative, intracellular pathogen causing the most important deep mycosis in Latin America. As the production of IFN-gamma and induction of cell-mediated immunity to P. brasiliensis is of critical importance in host defense, the immunotherapeutic effect of exogenous IL-12 administration was studied in a murine model of susceptibility to pulmonary infection. rIL-12 treatment led to a less disseminated disease, as confirmed by decreased fungal loads in liver and spleen. Administration of rIL-12 did not affect fungal growth in the lungs, although it did induce an augmented pulmonary mononuclear cell inflammation. IL-12 treatment induced an early (week 1) increase in pulmonary IFN-gamma, but decreased cytokine and specific antibody (IgG1 and IgG3) production at week 8 after infection. These results show that IL-12 administration induces a less severe infection, but the high inflammatory response detected in the lungs precludes its possible use as a new therapeutic tool for severe paracoccidioidomycosis. (C) 2002 Elsevier Science (USA).
Palavra-chave pulmonary mycosis
IL-12
paracoccidioidomycosis
cytokines
immunotherapy
Idioma Inglês
Data de publicação 2002-05-01
Publicado em Clinical Immunology. San Diego: Academic Press Inc Elsevier Science, v. 103, n. 2, p. 185-195, 2002.
ISSN 1521-6616 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 185-195
Fonte http://dx.doi.org/10.1006/clim.2002.5207
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000176082400009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26843

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