Morphologic and morphometric analyses of acetic acid-induced colitis in rats after treatment with enemas from Myracrodruon urundeuva Fr. All. (Aroeira do Sertao)

Morphologic and morphometric analyses of acetic acid-induced colitis in rats after treatment with enemas from Myracrodruon urundeuva Fr. All. (Aroeira do Sertao)

Autor Rodrigues, L. V. Google Scholar
Ferreira, F. V. Google Scholar
Regadas, FSP Google Scholar
Matos, D. Google Scholar
Viana, GSD Google Scholar
Instituição Fed Univ Ceara
Universidade Federal de São Paulo (UNIFESP)
Resumo The present work showed the effects of Myracrodruon urundeuva Fr. All., popularly known as 'aroeira' (AE), in the form of enemas prepared from the stem bark, on several morphologic and morphometric parameters after acetic acid-induced colitis in rats. Enemas from 5-ASA were used as standard while the vehicle, carboxymethylcellulose, was used as a control. the results of the morphological evaluation showed that on day I acetic acid produced significantly more necrosis in the groups treated with AE (10% and 20%) or 5-ASA than the controls. However, on day 60, there were more caliciform and absorptive cells in the treated groups compared with the controls. A significantly higher number of eosinophil and mononuclear cells and also collagen deposition in the controls compared with the treated groups were observed on day 60. However, a higher number of polymorphonuclear cells was detected on day 60 only in the AE treated group but not in the 5-ASA group. These data indicate that animals treated with AE or 5-ASA showed complete epithelial tissue regeneration, while in the controls chronic inflammatory exudate persisted and tissue regeneration occurred through fibrosis. Copyright (C) 2002 John Wiley Sons, Ltd.
Palavra-chave acetic acid-induced colitis
Myracrodruon urundeuva
crude extract
Idioma Inglês
Data de publicação 2002-05-01
Publicado em Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 16, n. 3, p. 267-272, 2002.
ISSN 0951-418X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 267-272
Fonte http://dx.doi.org/10.1002/ptr.841
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000175758100014
Endereço permanente http://repositorio.unifesp.br/handle/11600/26842

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