Energy balance of pregnant diabetic rats

Energy balance of pregnant diabetic rats

Autor Yamada, Ruth Autor UNIFESP Google Scholar
Griggio, Mauro Antonio Autor UNIFESP Google Scholar
Luz, Jacqueline Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Pregnancy and diabetes lead to metabolic alterations in the energy balance that may not be completely independent. the objective of the present study was to look at the alterations induced by type 1 diabetes mellitus on the energy balance of pregnant rats and the offspring. Diabetes was induced by streptozotocin injection 15 d before the starting of pregnancy. the rats had their energy balance variables followed for 21 d. Protein, fat and energy content of dams was determined from samples of the carcasses. Pregnancy led to increased energy intake, energy gain and energy expenditure as well as higher gross food efficiency than non-pregnant counterparts. Diabetes increased metabolizable energy intake but not the energy gain of the animals: they had very high energy expenditure, so that diabetes blocked the improvement in gross food efficiency shown during pregnancy. Offspring from diabetic dams were born with lower body weight. Pregnant animals did not present the usual energy storage as seen by lower energy gain of diabetic dams as well as by the lower fat content in the carcasses of pregnant diabetic rats. It is concluded that diabetes impairs the energy variables usually enhanced by pregnancy alone.
Palavra-chave energy balance
diabetes mellitus
pregnancy
energy expenditure
Idioma Inglês
Data de publicação 2002-05-01
Publicado em British Journal of Nutrition. Wallingford: C A B I Publishing, v. 87, n. 5, p. 509-515, 2002.
ISSN 0007-1145 (Sherpa/Romeo, fator de impacto)
Publicador C A B I Publishing
Extensão 509-515
Fonte http://dx.doi.org/10.1079/BJN2001520
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000175540000012
Endereço permanente http://repositorio.unifesp.br/handle/11600/26839

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