Systemic site of action for pressor effect of angiotensin II injected into the fourth cerebral ventricle of rats?

Systemic site of action for pressor effect of angiotensin II injected into the fourth cerebral ventricle of rats?

Autor Pesquero, João Bosco Autor UNIFESP Google Scholar
Fior-Chadi, Debora Rejane Autor UNIFESP Google Scholar
Yu, Yun-Guo Google Scholar
Merjan, Antonio J. Google Scholar
Lindsey, Charles Julian Autor UNIFESP Google Scholar
Paiva, Antonio Cechelli de Mattos Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Angiotensin II (ANG II) causes a systemic pressor effect when injected into the cerebral ventricles. in the rat fourth ventricle, the effective doses for the ANG II pressor effect are over 100 times larger than in the systemic circulation. Considering the discrepancy of doses, the possibility that ANG II may reach the systemic circulation and promote pressor effects, following injection into the fourth ventricle, was investigated. the effects on blood pressure of different vasoactive peptides that produce pressor responses when injected into the central nervous system were compared. Dose-response curves were obtained for intravenous or fourth cerebroventricular injections of ANG II, lysyl-vasopressin (LVP), bradykinin (BK), or endothelin-1 (ET-1). the ED50 ratios for intracerebroventricular/intraveneous injections were 110 for ANG II, 109 for LVP, 0.01 for BK, and approximately 0.4 for ET-1. in cross-circulation preparations, pressor responses occurred in the donor rat following injection into the fourth cerebral ventricle of the recipient animal, showing that effective doses of ANG II, administered to the fourth cerebral, reach the systemic circulation. the same results were obtained for the microinjection of 4 nmol of LVP into the fourth cerebral ventricle of recipient animals. High-performance reverse-phase liquid chromatography analyses of arterial blood showed that approximately 1% of the [I-125]ANG II injected into the fourth cerebral ventricle may be recovered from the systemic circulation a few seconds after the microinjection. the systemic administration of the ANG II receptor antagonist losartan blocked the response to ANG II injected into the fourth ventricle whereas antagonist administration in the same ventricle did not. Angiotensin injections into the lateral ventricle produced pressor responses that were reduced by antagonist administration to the same ventricle but not by systemic administration of the antagonist. the data suggest that the pressor effect resulting from ANG II or LVP injections into the fourth cerebral ventricle may be due to the action of this peptide in the systemic circulation. On the other hand, the pressor effect due to ANG II microinjection into the lateral ventricle apparently results from the direct stimulation of central periventricular structures.
Palavra-chave angiotensin
cerebral ventricles
pressor effect
systemic action
Idioma Inglês
Data de publicação 2002-05-01
Publicado em Canadian Journal of Physiology and Pharmacology. Ottawa: Natl Research Council Canada, v. 80, n. 5, p. 431-439, 2002.
ISSN 0008-4212 (Sherpa/Romeo, fator de impacto)
Publicador Natl Research Council Canada
Extensão 431-439
Fonte http://dx.doi.org/10.1139/Y02-062
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000175428800011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26838

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