Myocardial infarction scar plication in the rat: Cardiac mechanics in an animal model for surgical procedures

Myocardial infarction scar plication in the rat: Cardiac mechanics in an animal model for surgical procedures

Autor Kanashiro, Rosemeire M. Autor UNIFESP Google Scholar
Nozawa, Emilia Autor UNIFESP Google Scholar
Murad, Neif Autor UNIFESP Google Scholar
Gerola, Luis R. Autor UNIFESP Google Scholar
Moises, Valdir A. Google Scholar
Tucci, Paulo JF Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background. the immediate effects of surgical reduction of left ventricle cavity on cardiac mechanics have not been well defined.Methods. Cardiac mechanics were analyzed before and after myocardial infarction scar plication in 11 isolated infarcted rat hearts.Results. Despite a decrease in myocardial stiffness, an increase in chamber stiffness was noted after myocardial infarction scar plication. Systolic function was favored in more than one way. for the same diastolic pressures, maximal developed pressures were higher after myocardial infarction scar plication, and the slope of the systolic pressure-volume relationship was steeper afterwards as compared with before; this means that Frank-Starling recruitment is accentuated in smaller cavities. in addition, the developed net forces needed to generate these pressures were clearly lower afterward than before, indicating reduced ventricular afterload.Conclusions. the study results show that diastolic function is harmed and systolic function is favored by myocardial infarction scar plication. We suggest that preoperative evaluation of the degree of diastolic dysfunction and impairment of the Frank-Starling mechanism may help to identify patients who may have a poor postoperative outcome due to diastolic or systolic dysfunction.
Idioma Inglês
Data de publicação 2002-05-01
Publicado em Annals of Thoracic Surgery. New York: Elsevier B.V., v. 73, n. 5, p. 1507-1513, 2002.
ISSN 0003-4975 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1507-1513
Fonte http://dx.doi.org/10.1016/S0003-4975(01)03416-6
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000175513100032
Endereço permanente http://repositorio.unifesp.br/handle/11600/26835

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