Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients

Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients

Autor Morelli, V. M. Google Scholar
Lourenco, D. M. Google Scholar
D'Almeida, V Google Scholar
Franco, R. F. Google Scholar
Miranda, F. Google Scholar
Zago, M. A. Google Scholar
Noguti, MAE Google Scholar
Cruz, E. Google Scholar
Kerbauy, J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Fasting total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation were evaluated in 91 patients with venous thromboembolism and without acquired thrombophilia, and in 91 age-matched and sex-matched controls. Hyperhomocysteinemia was detected in 11 patients (12.1%) and in two controls (2.2%), yielding an odds ratio (OR) for venous thrombosis of 6.1 [95% confidence interval (CI), 1.3-28.4]. After excluding 21 patients and four controls with other known genetic risk factors for venous thrombosis, the OR was not substantially changed (7.0; 95% Cl, 1.5-33.1). the prevalence of the MTHFR 677TT genotype was not significantly different in patients (9.9%) and in controls (5.5%), with an OR for venous thrombosis of 1.8 (95% CI, 0.6-5.8). Subjects with the MTHFR 677TT genotype showed higher levels of tHcy compared with the 677CC genotype in patients (P=0.010) and in controls (P=0.030). in conclusion, we found that fasting hyperhomocysteinemia is a risk factor for venous thrombosis in patients without known acquired thrombophilia and other genetic risk factors for venous thrombosis. Although tHcy levels are significantly higher in those homozygous for the MTHFR C677T mutation, this genotype does not increase the thrombotic risk in our study population. (C) 2002 Lippincott Williams Wilkins.
Palavra-chave hyperhomocysteinemia
methylenetetrahydrofolate reductase
venous thromboembolism
Brazilian
risk factor
Idioma Inglês
Data de publicação 2002-04-01
Publicado em Blood Coagulation & Fibrinolysis. Philadelphia: Lippincott Williams & Wilkins, v. 13, n. 3, p. 271-275, 2002.
ISSN 0957-5235 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 271-275
Fonte http://dx.doi.org/10.1097/00001721-200204000-00014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000175547400014
Endereço permanente http://repositorio.unifesp.br/handle/11600/26831

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