Thrombopoietin serum levels do not correlate with thrombocytopenia in hepatic schistosomiasis

Thrombopoietin serum levels do not correlate with thrombocytopenia in hepatic schistosomiasis

Autor Souza, MRA Google Scholar
Aguiar, LAK Google Scholar
Goto, J. M. Google Scholar
Carvente, C. T. Google Scholar
Toledo, C. F. Google Scholar
Borges, D. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: in severe forms of cirrhosis reduced liver synthesis of thrombopoietin (Tpo) can contribute to thrombocytopenia. in the hepatosplenic form of schistosomiasis, portal hypertension is the most evident clinical complication, although a deficiency of protein synthesis may be detected early. Our aim was to determine, for the first time in schistosomiasis, Tpo serum concentrations in patients with chronic forms of the disease. Method Twenty-four patients with the pure form of schistosomiasis were studied; 13 had the hepatosplenic form (HE, with portal hypertension) and 11 had the hepatointestinal form (HI, without portal hypertension). Patients were HBsAg, anti-HBc and anti-HCV negative, and reported alcohol ingestion below 160 g/week. Results: the Tpo serum concentration, determined in 10 healthy volunteers, varied from undetectable (< 15 pg/mL) to 489 pg/mL (median 208 pg/mL). the HE and HI groups differed (p = 0.004) in regard to the prothrombin index, thrombocytemia and &gamma;-glutamyltransferase but not in regard to Tpo (p = 0.622). No significant correlation was found between Tpo and the other parameters (p > 0.05). Conclusions: the results suggest that Tpo serum concentration does not mirror and/or has no significant participation in the mechanisms responsible for the thrombocytopenia observed in schistosomiasis patients with splenomegaly and portal hypertension.
Palavra-chave schistosomiasis
thrombocytemia
thrombopoietin
splenomegaly
portal hypertension
Idioma Inglês
Data de publicação 2002-04-01
Publicado em Liver. Copenhagen: Blackwell Munksgaard, v. 22, n. 2, p. 127-129, 2002.
ISSN 0106-9543 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Munksgaard
Extensão 127-129
Fonte http://dx.doi.org/10.1034/j.1600-0676.2002.01574.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000176099400006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26822

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