Ocular toxoplasmosis: More than just what meets the eye

Ocular toxoplasmosis: More than just what meets the eye

Autor Vallochi, A. L. Google Scholar
Nakamura, M. V. Google Scholar
Schlesinger, D. Google Scholar
Martins, Maria Cristina Autor UNIFESP Google Scholar
Silveira, C. Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Rizzo, L. V. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Toxoplasma gondii is an intracellular parasite whose life cycle may include the man as an intermediate host. Close to a billion people are infected with this parasite worldwide. Ocular lesions may occur in up to 25% of those individuals infected. the infection may occur intra-uterus, through the placenta when the mother is infected during pregnancy. the parasite may also infect adults after the ingestion of contaminated food products. most notably meats or water. We have shown that although congenital and post-natal (acquired) infection results in similar ocular lesions, the immunological mechanisms behind the development of disease are different. On the other hand, contrary to published data obtained in mice, we were unable to find evidence that the T. gondii express superantigen activity for human lymphocytes. Our findings are important because they suggest that superantigen activity is not important as a pathological mechanism in human disease. Our data also suggest that, whereas the ocular lesion caused by infection after birth is the result of an excessive or dysfunctional immune response, the lesions caused by congenital infection may be due to a lack of an appropriate response to the parasite.
Idioma Inglês
Data de publicação 2002-04-01
Publicado em Scandinavian Journal of Immunology. Oxford: Blackwell Publishing Ltd, v. 55, n. 4, p. 324-328, 2002.
ISSN 0300-9475 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing Ltd
Extensão 324-328
Fonte http://dx.doi.org/10.1046/j.1365-3083.2002.01052.x
Direito de acesso Acesso aberto Open Access
Tipo Resenha
Web of Science WOS:000175115000003
Endereço permanente http://repositorio.unifesp.br/handle/11600/26806

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