Use of amifostine in the therapy of osteosarcoma in children and adolescents

Use of amifostine in the therapy of osteosarcoma in children and adolescents

Author Petrilli, A. S. Google Scholar
Oliveira, D. T. Google Scholar
Ginani, V. C. Google Scholar
Kechichian, R. Google Scholar
Dishtchekenian, A. Google Scholar
Roque, W. D. Google Scholar
Tanaka, C. Google Scholar
Dias, C. G. Google Scholar
Latorre, M. D. Google Scholar
Brunetto, A. L. Google Scholar
Cardoso, H. Google Scholar
Almeida, M. T. Google Scholar
Camargo, B. de Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Clin Porto Alegre
Universidade de São Paulo (USP)
Abstract Amifostine protects normal tissue from the cytotoxic damage induced by radiation and chemotherapy. in this study. 39 consecutive newly diagnosed children with osteosarcoma were assessed; 20 received amifostine and 19 did not. the chemotherapy regimen included an induction phase of three cycles of cisplatin (100 mg/m(2)), carboplatin (500 mg/m(2)), and doxorubicin (60 mg/m(2)), followed by surgery. Alternating cycles of cisplatin/ifosfamide (9 mg/m(2)), ifosfamide/doxorubicin. carboplatin/doxorubicin, and ifosfamide/carboplatin were administered every 3 weeks to complete 26 weeks of treatment. Amifostine was administered 15 minutes before the infusions of cisplatin and carboplatin in a total of 193 infusions. Side effects during infusions and renal, hearing, and bone marrow toxicities were evaluated and compared between the two groups. Hypotension was observed in 28 (14.5%) infusions. No patient required discontinuation of therapy. Fewer than two episodes of vomiting occurred in 130 (71%) infusions and two to five episodes occurred in 51 (28%) infusions. and no patient had grade 4 toxicity. There was no difference between the two groups regarding renal toxicity (creatinine clearance). Neutropenia and leukopenia were significantly less frequent in the amifostine group. No difference was observed in platelet and hearing toxicities. Amifostine was well tolerated in doses of 740 mg/m(2) in children and adolescents, and myelotoxicity was less severe in the amifostine group. This was a pilot study for further evaluation in a larger randomized trial.
Keywords amifostine
children and adolescents
Language English
Date 2002-03-01
Published in Journal of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 24, n. 3, p. 188-191, 2002.
ISSN 1077-4114 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 188-191
Access rights Closed access
Type Article
Web of Science ID WOS:000174910300005

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