Liver necrosis induced by acute intraperitoneal ethanol administration in aged rats

Liver necrosis induced by acute intraperitoneal ethanol administration in aged rats

Autor Giavarotti, L. Google Scholar
D'Almeida, V Google Scholar
Giavarotti, KAS Google Scholar
Azzalis, L. A. Google Scholar
Rodrigues, L. Google Scholar
Cravero, AAM Google Scholar
Videla, L. A. Google Scholar
Koch, O. R. Google Scholar
Junqueira, VBC Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Buenos Aires
Univ Chile
Resumo It is generally agreed that the deleterious pathophysiological effects of ethanol are caused, at least partially by an increase in free radical production. However, little attention has been directed to the effects of ethanol upon elderly organisms. Male Wistar rats at ages 3, 6,12,18 and 24 months were treated either with a single i.p. dose of 35% ethanol (v/v) at 3 g ethanol/kg body weight or an isovolumetric amount of 0.9% saline solution. We then assessed the plasma levels of transaminases and hepatic levels of oxidative stress-related parameters, followed by liver histological evaluation. the younger rats (3 months old) were not affected by the treatment with ethanol with respect to any of the studied parameters except for a lowering of total hepatic GSH and an increase in hepatic thiobarbituric acid reactants (TBARS) formation, while animals older than 3 months were increasingly more affected by the treatment. Acute ethanol treatment elicited the similar responses to those in the 3 months-old group, plus a decrease in the hepatic and plasma levels of beta-carotene and the plasma level of alpha-tocopherol, as well as an increase in the activity of plasma transaminases. in the 12,18 and 24 months old groups, there was increasing liver necrosis. These findings suggest that liver damage induced by acute ethanol administration in elderly rats may involve a lack of antioxidants.
Palavra-chave aging
alcoholism
liver injury
oxidative stress
Idioma Inglês
Data de publicação 2002-03-01
Publicado em Free Radical Research. Abingdon: Taylor & Francis Ltd, v. 36, n. 3, p. 269-275, 2002.
ISSN 1071-5762 (Sherpa/Romeo, fator de impacto)
Publicador Taylor & Francis Ltd
Extensão 269-275
Fonte http://dx.doi.org/10.1080/10715760290019282
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000174725300005
Endereço permanente http://repositorio.unifesp.br/handle/11600/26792

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