Paradoxical sleep deprivation facilitates subsequent corticosterone response to a mild stressor in rats

Paradoxical sleep deprivation facilitates subsequent corticosterone response to a mild stressor in rats

Autor Suchecki, D. Google Scholar
Tiba, P. A. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The pituitary-ad renal responsiveness to a mild stressor was assessed in rats that were deprived of paradoxical sleep (PS) and in controls that were not deprived. Animals were either individually- or group-deprived for 96 h and hormone levels were assessed at 0, 5, 20 or 60 min after a saline injection + novelty and compared with rats which were not deprived. Both types of PS deprivation resulted in elevated adrenocorticotropin levels at 0 min, which peaked at 5 min in all animals. Individually-deprived rats exhibited the highest corticosterone (CORT) levels at 0 min. Peak levels were higher and occurred earlier in PS-deprived than in control rats (5 vs. 20 min, respectively). At 20 min, CORT levels had already returned to unstressed levels in PS-deprived rats, but not in control rats. These data indicate that PS deprivation induces facilitation of the adrenocortical response to a mild stressor, but do not suggest that PS deprivation changes the negative feedback sensitivity to CORT. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Palavra-chave paradoxical sleep deprivation
pituitary-adrenal axis
facilitation
sleep
stress
rat
Idioma Inglês
Data de publicação 2002-03-01
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 320, n. 1-2, p. 45-48, 2002.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 45-48
Fonte http://dx.doi.org/10.1016/S0304-3940(02)00024-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000174102700012
Endereço permanente http://repositorio.unifesp.br/handle/11600/26784

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