Benefits of soy isoflavone therapeutic regimen on menopausal symptoms

Benefits of soy isoflavone therapeutic regimen on menopausal symptoms

Autor Han, K. K. Google Scholar
Soares, J. M. Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Lima, G. R. de Google Scholar
Baracat, E. C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To examine the change in menopausal symptoms and cardiovascular risk factors in response to 4 months of daily 100-mg soy isoflavone in postmenopausal women.METHODS: in this double-blind, placebo-controlled study, 80 women were randomly assigned to isoflavone (n = 40) and placebo (n = 40) treatment. the menopausal Kupper-man index was used to assess change in menopausal symptoms at baseline and after 4 months of treatment. Cardiovascular risk factors were assessed by evaluating plasma lipid levels, body mass index, blood pressure, and glucose levels in the participants. To examine the effects of this regime on endogenous hormone levels, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and 17beta-estradiol were measured. Transvaginal sonography was performed to quantify endometrial thickness.RESULTS: the data showed a decrease in menopausal symptoms (P < .01, paired t test, two-tailed, between baseline and isoflavone groups, and P < .01, unpaired ttest, between placebo and isoflavone groups). Total cholesterol and low-density lipoprotein decreased significantly in the isoflavone group compared with the baseline or placebo group (P < .001, paired ttest, two-tailed, between baseline and isoflavone groups, and P < .01, unpaired t test, between placebo and isoflavone groups). the isoflavone treatment appeared to have no effect on blood pressure, plasma glucose, and high-density lipoprotein and triglyceride levels.CONCLUSION: This study suggests that isoflavone 100-mg regime treatment may be a safe and effective alternative therapy for menopausal symptoms and may offer a benefit to the cardiovascular system. (C) 2002 by the American College of Obstetricians and Gynecologists.
Idioma Inglês
Data de publicação 2002-03-01
Publicado em Obstetrics and Gynecology. New York: Elsevier B.V., v. 99, n. 3, p. 389-394, 2002.
ISSN 0029-7844 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 389-394
Fonte http://dx.doi.org/10.1016/S0029-7844(01)01744-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000174010300005
Endereço permanente http://repositorio.unifesp.br/handle/11600/26768

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