Early benefits of pravastatin to experimentally induced atherosclerosis

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dc.contributor.author Silva, E. P. [UNIFESP]
dc.contributor.author Fonseca, FAH [UNIFESP]
dc.contributor.author Ihara, SSM [UNIFESP]
dc.contributor.author Izar, COM [UNIFESP]
dc.contributor.author Lopes, I. L. [UNIFESP]
dc.contributor.author Pinto, LESA [UNIFESP]
dc.contributor.author Badimon, J. J.
dc.contributor.author Tuffik, S.
dc.contributor.author Paiva, T. B. [UNIFESP]
dc.contributor.author Kasinski, N. [UNIFESP]
dc.contributor.author Paola, A. V. de [UNIFESP]
dc.contributor.author Carvalho, ACC [UNIFESP]
dc.date.accessioned 2016-01-24T12:33:15Z
dc.date.available 2016-01-24T12:33:15Z
dc.date.issued 2002-03-01
dc.identifier http://dx.doi.org/10.1097/00005344-200203000-00010
dc.identifier.citation Journal of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 3, p. 389-395, 2002.
dc.identifier.issn 0160-2446
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26760
dc.description.abstract There is little information regarding the time of hypolipidemic treatment of changes in atherosclerotic plaque, tissue cholesterol content. and also for the recovery of endothelial function. To assess the early effects of lipid-lowering treatment on these parameters, six groups of New Zealand male rabbits were studied. Animals in groups I and 11 were fed regular chow; groups III and IV received a 12-week 0.5% cholesterol diet followed by 12 weeks of 0.05% cholesterol diet. Finally, groups V and VI were fed a 12-week 0.5% cholesterol diet and were then shifted to a regular diet for 12 weeks. During the last four weeks, the rabbits in groups I. 111, and V received low-dose pravastatin (2 mg/day), added to the diet. Group IV animals had the highest cholesterol plasma levels (vs. groups 1, 11, III. and V, p < 0.01) and presented atherosclerotic plaques in a more advanced stage. Nonatherogenic diet was insufficient to restore endothelial function in animals previously fed cholesterol-enriched diets (groups IV and VI). Conversely, pravastatin treatment promoted significant improvement in endothelial function and reduced the progression of atherosclerosis. Marked increase in cholesterol content was seen in aorta and liver in response to the atherogenic diet. However, neither treatment with pravastatin nor nonatherogenic diet was capable of modifying the tissue cholesterol content. Our study supports the hypothesis that the early use of statins can attenuate the progression of atherosclerosis and ameliorate endothelial function. in addition, significant changes in the tissue cholesterol pool probably need a longer period of treatment. en
dc.format.extent 389-395
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal of Cardiovascular Pharmacology
dc.rights Acesso aberto
dc.subject atherosclerosis en
dc.subject endothelium en
dc.subject experimental en
dc.subject lipids en
dc.subject pravastatin en
dc.title Early benefits of pravastatin to experimentally induced atherosclerosis en
dc.type Artigo
dc.contributor.institution Mt Sinai Sch Med
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Mt Sinai Sch Med, New York, NY USA
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1097/00005344-200203000-00010
dc.description.source Web of Science
dc.identifier.wos WOS:000174058900010


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