Early benefits of pravastatin to experimentally induced atherosclerosis

Early benefits of pravastatin to experimentally induced atherosclerosis

Author Silva, E. P. Autor UNIFESP Google Scholar
Fonseca, FAH Autor UNIFESP Google Scholar
Ihara, SSM Autor UNIFESP Google Scholar
Izar, COM Autor UNIFESP Google Scholar
Lopes, I. L. Autor UNIFESP Google Scholar
Pinto, LESA Autor UNIFESP Google Scholar
Badimon, J. J. Google Scholar
Tuffik, S. Google Scholar
Paiva, T. B. Autor UNIFESP Google Scholar
Kasinski, N. Autor UNIFESP Google Scholar
Paola, A. V. de Autor UNIFESP Google Scholar
Carvalho, ACC Autor UNIFESP Google Scholar
Institution Mt Sinai Sch Med
Universidade Federal de São Paulo (UNIFESP)
Abstract There is little information regarding the time of hypolipidemic treatment of changes in atherosclerotic plaque, tissue cholesterol content. and also for the recovery of endothelial function. To assess the early effects of lipid-lowering treatment on these parameters, six groups of New Zealand male rabbits were studied. Animals in groups I and 11 were fed regular chow; groups III and IV received a 12-week 0.5% cholesterol diet followed by 12 weeks of 0.05% cholesterol diet. Finally, groups V and VI were fed a 12-week 0.5% cholesterol diet and were then shifted to a regular diet for 12 weeks. During the last four weeks, the rabbits in groups I. 111, and V received low-dose pravastatin (2 mg/day), added to the diet. Group IV animals had the highest cholesterol plasma levels (vs. groups 1, 11, III. and V, p < 0.01) and presented atherosclerotic plaques in a more advanced stage. Nonatherogenic diet was insufficient to restore endothelial function in animals previously fed cholesterol-enriched diets (groups IV and VI). Conversely, pravastatin treatment promoted significant improvement in endothelial function and reduced the progression of atherosclerosis. Marked increase in cholesterol content was seen in aorta and liver in response to the atherogenic diet. However, neither treatment with pravastatin nor nonatherogenic diet was capable of modifying the tissue cholesterol content. Our study supports the hypothesis that the early use of statins can attenuate the progression of atherosclerosis and ameliorate endothelial function. in addition, significant changes in the tissue cholesterol pool probably need a longer period of treatment.
Keywords atherosclerosis
Language English
Date 2002-03-01
Published in Journal of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 3, p. 389-395, 2002.
ISSN 0160-2446 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 389-395
Origin http://dx.doi.org/10.1097/00005344-200203000-00010
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000174058900010
URI http://repositorio.unifesp.br/handle/11600/26760

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