The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats

The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats

Autor Calvente, PRV Google Scholar
Araujo, CCS Google Scholar
Bergamo, M. Google Scholar
Abilio, V. C. Google Scholar
D'Almeida, V Google Scholar
Ribeiro, RDA Google Scholar
Frussa, R. Google Scholar
Instituição Dept Farmacol
Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., die frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg ip, every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, sc, every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia. (C) 2001 Elsevier Science Inc. All rights reserved.
Palavra-chave rat
reserpine
tardive dyskinesia
tongue protrusion
3-nitropropionic acid
Idioma Inglês
Data de publicação 2002-02-01
Publicado em Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 26, n. 2, p. 401-405, 2002.
ISSN 0278-5846 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 401-405
Fonte http://dx.doi.org/10.1016/S0278-5846(01)00255-X
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000173005700028
Endereço permanente http://repositorio.unifesp.br/handle/11600/26749

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