Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation

Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation

Autor Kondo, Claudia Seiko Autor UNIFESP Google Scholar
Macchionne, Mariangela Google Scholar
Nakagawa, Naomi Kondo Autor UNIFESP Google Scholar
Carvalho, Carlos Roberto Ribeiro de Google Scholar
King, Malcolm Google Scholar
Saldiva, Paulo Hilario Nascimento Google Scholar
Lorenzi-Filho, Geraldo Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Pulm Res Grp
Resumo The use of intravenous (IV) furosemide is common practice in patients under mechanical ventilation (MV), but its effects on respiratory mucus are largely unknown. Furosemide can affect respiratory mucus either directly through inhibition of the NaK(Cl)(2) co-transporter on the basolateral surface of airway epithelium or indirectly through increased diuresis and dehydration. We investigated the physical properties and transportability of respiratory mucus obtained from 26 patients under MV distributed in two groups, furosemide (n=12) and control (n=14). Mucus collection was done at 0, 1, 2, 3 and 4 hours. the rheological properties of mucus were studied with a microrheometer, and in vitro mucociliary transport (MCT) (frog palate), contact angle (CA) and cough clearance (CC) (simulated cough machine) were measured. After the administration of furosemide, MCT decreased by 17+/-19%, 24+/-11%, 18+/-16% and 18+/-13% at 1, 2, 3 and 4 hours respectively, P<0.001 compared with control. in contrast, no significant changes were observed in the control group. the remaining parameters did not change significantly in either group. Our results support the hypothesis that IV furosemide might acutely impair MCT in patients under MV.
Palavra-chave furosemide
mechanical ventilation
mucociliary transport
mucus rheology
Idioma Inglês
Data de publicação 2002-02-01
Publicado em Critical Care. London: Biomed Central Ltd, v. 6, n. 1, p. 81-87, 2002.
ISSN 1466-609X (Sherpa/Romeo, fator de impacto)
Publicador Biomed Central Ltd
Extensão 81-87
Fonte http://dx.doi.org/10.1186/cc1458
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000174363900018
Endereço permanente http://repositorio.unifesp.br/handle/11600/26742

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