Tonin and kallikrein in the brain of transgenic rat line expressing human tissue kallikrein

Tonin and kallikrein in the brain of transgenic rat line expressing human tissue kallikrein

Autor Lomez, ESL Google Scholar
Araujo, R. C. Google Scholar
Bader, Michael Autor UNIFESP Google Scholar
Pesquero, João Bosco Autor UNIFESP Google Scholar
Pesquero, J. L. Google Scholar
Instituição Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Max Delbruck Ctr Mol Med
Resumo A transgenic rat line harboring the human tissue kallikrein gene was investigated for expression and activity of tonin and kallikrein in different regions of the brain. the introduction of the transgene into the rat genome produced a significant augmentation of the expression levels and activity of rat tissue kallikrein. the possibility that human kallikrein does not hydrolyze the rat substrate is probably responsible for the augmented expression of the rat enzyme. On the other hand, although expression of tonin was significantly reduced, tonin activity was not altered in most brain structures, except for cerebellum and neurohypophysis.
Assunto tonin
kallikrein
angiotensin II
rats
brain
Idioma Inglês
Data 2002-02-01
Publicado em Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 2, p. 229-232, 2002.
ISSN 0194-911X (Sherpa/Romeo, fator de impacto)
Editor Lippincott Williams & Wilkins
Extensão 229-232
Fonte http://dx.doi.org/10.1161/hy0202.104264
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000174045700008
URI http://repositorio.unifesp.br/handle/11600/26741

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