Metoclopramide-induced hyperprolactinemia affects mouse endometrial morphology

Metoclopramide-induced hyperprolactinemia affects mouse endometrial morphology

Autor Rossi, AGZ Google Scholar
Soares, J. M. Google Scholar
Motta, ELA Google Scholar
Simoes, M. J. Google Scholar
Oliveira, R. M. Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Lima, G. R. de Google Scholar
Baracat, E. C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Information about the effects of pituitary hyperprolactinemia on endometrium, especially in levels coexisting with absence of amenorrhea in women, is scarce. the interference of high prolactin levels on endometrial morphology was thus investigated in young post-pubertal and adult mice rendered hyperprolactinemic by long-term treatment with metoclopramide (MC). No remarkable differences have been noticed upon light microscopy examination of the endometria comparing young to adult cycling MC-treated mice, except on the max/min diameter ratio, which in young animals was lower than in adults (ANOVA, p < 0.01). Both young and adult MC-treated mice presented an increased number of endometrial glands than their respective controls (ANOVA, p < 0.01). However, young MC-treated animals showed the highest values of endometrial thickness index compared to other groups (ANOVA, p < 0.01). Our results indicate that MC-induced hyperprolactinemia causes mouse endometrium proliferation, mainly in young animals.
Palavra-chave mouse
hyperprolactinemia
metoclopramide
endometrium
Idioma Inglês
Data de publicação 2002-01-01
Publicado em Gynecologic and Obstetric Investigation. Basel: Karger, v. 54, n. 4, p. 185-190, 2002.
ISSN 0378-7346 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 185-190
Fonte http://dx.doi.org/10.1159/000068380
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000181455000001
Endereço permanente http://repositorio.unifesp.br/handle/11600/26724

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