Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002

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dc.contributor.author Ohe, Monique Nakayama [UNIFESP]
dc.contributor.author Santos, Rodrigo Oliveira [UNIFESP]
dc.contributor.author Barros, Elizabete Ribeiro [UNIFESP]
dc.contributor.author Lage, Andrea Zacouteguy [UNIFESP]
dc.contributor.author Kunii, Ilda Sizue [UNIFESP]
dc.contributor.author Abrahão, Márcio [UNIFESP]
dc.contributor.author Cervantes, Onivaldo [UNIFESP]
dc.contributor.author Hauache, Omar Magid [UNIFESP]
dc.contributor.author Lazaretti-Castro, Marise [UNIFESP]
dc.contributor.author Vieira, José Gilberto Henriques [UNIFESP]
dc.date.accessioned 2015-06-14T13:31:43Z
dc.date.available 2015-06-14T13:31:43Z
dc.date.issued 2005-09-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2005000900013
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 9, p. 1383-1387, 2005.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2671
dc.description.abstract In contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases diagnosed/year increased from 1.8/year in the first group to 6.0/year in the second group and 8.1/year in the third group. The first group comprised 9 patients (mean serum calcium ± SD, 13.6 ± 1.6 mg/dl), 8 of them (88.8%) defined as symptomatic. The second group comprised 30 patients (mean calcium ± SD, 12.2 ± 1.63 mg/dl), 22 of them defined as symptomatic (73.3%). The third group contained 65 patients (mean calcium 11.7 ± 1.1 mg/dl), 34 of them symptomatic (52.3%). Patients from the first group tended to be younger (mean ± SD, 43.0 ± 15 vs 55.1 ± 14.4 and 55.7 ± 17.3 years, respectively) and their mean serum calcium was significantly higher (P < 0.05). All of symptomatic patients independent of group had higher serum calcium levels (12.4 ± 1.53 mg/dl, N = 64) than asymptomatic patients (11.4 ± 1.0 mg/dl, N = 40). Our data showed an increase in the percentage of asymptomatic patients over the years in the number of primary hyperparathyroidism cases diagnosed. This finding may be due to an increased availability of diagnostic methods and/or to an increased awareness about the disease. en
dc.format.extent 1383-1387
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Primary hyperparathyroidism en
dc.subject Hypercalcemia en
dc.subject Clinical presentation en
dc.subject Asymptomatic primary hyperparathyroidism en
dc.subject Parathyroid hormone en
dc.subject Hyperparathyroidism en
dc.title Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002 en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Medicina
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.identifier.file S0100-879X2005000900013.pdf
dc.identifier.scielo S0100-879X2005000900013
dc.identifier.doi 10.1590/S0100-879X2005000900013
dc.description.source SciELO
dc.identifier.wos WOS:000231773600013



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