Verbal fluency facilitated by the cholinergic blocker, scopolamine

Verbal fluency facilitated by the cholinergic blocker, scopolamine

Autor Pompeia, S. Google Scholar
Rusted, J. M. Google Scholar
Curran, H. V. Google Scholar
Instituição Univ Sussex
Universidade Federal de São Paulo (UNIFESP)
UCL
Resumo This study was designed to explore putative facilitatory effects of low doses of scopolamine (SP) on phonemic (letter) and semantic (category) verbal fluency. A double-blind, parallel-group design was used with 36 subjects who completed a test battery before and 2 h after 0.6 mg or 1.2 mg of SP or placebo. Fluency measures included total number of words generated, clustering (the production of words within semantic or phonemic subcategories) and switching (the ability to shift efficiently to new subcategories). Low doses of scopolamine increased phonemic fluency, as has been shown previously. Semantic fluency was not increased by SP, although subjects treated with 1.2 mg of SP generated higher-frequency words. SP did not affect clustering or switching. It is suggested that phonemic and semantic fluency reflect distinct cognitive processes. Copyright (C) 2002 John Wiley Sons, Ltd.
Palavra-chave scopolamine
anticholinergic
muscarinic antagonist
verbal fluency
semantic memory
clustering
switches
Idioma Inglês
Data de publicação 2002-01-01
Publicado em Human Psychopharmacology-clinical and Experimental. Malden: Wiley-Blackwell, v. 17, n. 1, p. 51-59, 2002.
ISSN 0885-6222 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 51-59
Fonte http://dx.doi.org/10.1002/hup.331
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000173604200006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26691

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