Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni

Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni

Autor Jesus, A. R. de Google Scholar
Silva, A. Google Scholar
Santana, L. B. Google Scholar
Magalhaes, A. Google Scholar
Jesus, A. A. de Google Scholar
Almeida, R. P. de Google Scholar
Rego, MAV Google Scholar
Burattini, Marcelo Nascimento Autor UNIFESP Google Scholar
Pearce, E. J. Google Scholar
Carvalho, E. M. Google Scholar
Instituição Universidade Federal da Bahia (UFBA)
Univ Fed Sergipe
Universidade Federal de São Paulo (UNIFESP)
Cornell Univ
Resumo Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)-alpha, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean +/- SD, 7.8 +/- 7.6 mug Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean +/- SD) of TNF-alpha (1349.3 +/- 767.6 pg/mL), interleukin (IL)-1 (2683 +/- 1270 mug/mL), and IL-6 (382 +/- 52.3 pg/mL) were elevated in PBMC. Serum TNF-alpha levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-gamma levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis.
Idioma Inglês
Data de publicação 2002-01-01
Publicado em Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 185, n. 1, p. 98-105, 2002.
ISSN 0022-1899 (Sherpa/Romeo, fator de impacto)
Publicador Univ Chicago Press
Extensão 98-105
Fonte http://dx.doi.org/10.1086/324668
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000172722600013
Endereço permanente http://repositorio.unifesp.br/handle/11600/26689

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