Immunohistochemical study of six cases of Taylor's type focal cortical dysplasia: Correlation with electroclinical data

Immunohistochemical study of six cases of Taylor's type focal cortical dysplasia: Correlation with electroclinical data

Autor Lurton, Dominique Marie François Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Sanabria, Emilio Rafael Garrido Autor UNIFESP Google Scholar
Silva, Alexandre Valotta da Autor UNIFESP Google Scholar
Vianna, R. Google Scholar
Garzon, Eliana Autor UNIFESP Google Scholar
Sakamoto, Américo Ceiki Autor UNIFESP Google Scholar
Spreafico, R. Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Alemao Oswaldo Cruz
Ist Nazl Neurol Carlo Besta
Resumo Purpose: Cortical specimens from six patients operated on for drug-resistant epilepsy diagnosed as Taylor's type focal cortical dysplasia were submitted to neuropathological and immunohistochemical studies.Methods: All patients were submitted to presurgical investigations including clinical and neuropsychological evaluations, EEG/video telemetry of ictal and interictal events, magnetic resonance imaging, and ictal and interictal single-photon emission computed tomography (SPECT). Recordings from electrocorticography (ECoG) were obtained in four cases and from subdural electrode implantation in two. Postsurgical follow-up was assessed according to Engel's score. Immunohistochemistry (IHC) was processed for parvalbumin (PV), calbindin D28-K (CB), nonphosphorylated neurofilaments (SMI-311), glial fibrillary acidic protein (GFAP) in all cases.Results: We found continuous/quasi-continuous spikes and sharp-wave patterns in three cases and frequent repetitive bursting of polyspikes and ECoG seizures in two cases. Every patient showed cortical dyslamination, abnormal and giant neurons, and balloon cells. GFAP immunoreactivity was found in astrocytes and some balloon cells that were less intensely stained. Nonphosphorylated neurofilaments SMI-311 immunoreactivity was found in normal and giant neurons and in some balloon cells, making visible thin neuropils. PV immunoreactivity was present in normal interneurons and in fibers in layers IV-V. PV-negative balloon cells were surrounded by abundant PV-positive fibers. CB immunoreactivity was found mostly in interneurons in layers II-III.Conclusions: Our research is inconclusive. More cases should be investigated, and we must draw more accurate anatomic correlations between the ECoG recordings and surgical specimens studied with IHC.
Assunto cortical dysplasia
Idioma Inglês
Data 2002-01-01
Publicado em Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 217-219, 2002.
ISSN 0013-9580 (Sherpa/Romeo, fator de impacto)
Editor Blackwell Publishing Inc
Extensão 217-219
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000177445900040

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