Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy

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dc.contributor.author Garzillo, Cibele Larrosa [UNIFESP]
dc.contributor.author Mello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.date.accessioned 2016-01-24T12:33:10Z
dc.date.available 2016-01-24T12:33:10Z
dc.date.issued 2002-01-01
dc.identifier http://dx.doi.org/10.1046/j.1528-1157.43.s.5.40.x
dc.identifier.citation Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 107-109, 2002.
dc.identifier.issn 0013-9580
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26685
dc.description.abstract Purpose: Astrogliosis is a prominent finding in human temporal lobe epilepsy. Work in animal models of temporal lobe epilepsy, however, have mostly concentrated on the acute phases of the studied models or have failed to demonstrate reactive gliosis during the chronic phases of such models.Methods: Here we used the pilocarpine model of chronic seizures and Cajal's gold sublimate technique for the staining reactive astrocytes to study this issue.Results: for half of the animals (nine of 17) subject to pilocarpine-induced status epilepticus (SE), when assessed 60 days later, variable levels of reactive astrocytes were seen in many thalamic, hippocampal, amygdalar, and neocortical areas. for the remaining half of the animals, however (eight of 17), despite a similar SE induction, as well as for controls, we could not detect stained reactive astrocytes.Conclusions: We hypothesize that these results might underlie possible differences in the frequency of recurrent spontaneous seizures. en
dc.format.extent 107-109
dc.language.iso eng
dc.publisher Blackwell Publishing Inc
dc.relation.ispartof Epilepsia
dc.rights Acesso aberto
dc.subject spontaneous seizures en
dc.subject epileptogenesis en
dc.subject gliosis en
dc.subject temporal lobe epilepsy en
dc.subject neuronal damage en
dc.subject neurodegeneration en
dc.title Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1046/j.1528-1157.43.s.5.40.x
dc.description.source Web of Science
dc.identifier.wos WOS:000177445900019



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