Haemophilus influenzae resistance in Latin America: Systematic review of surveillance data

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dc.contributor.author Andrade, Ana Lúcia Sampaio Sgambatti de
dc.contributor.author Brandileone, Maria Cristina
dc.contributor.author Di Fabio, José Luis
dc.contributor.author Oliveira, Renato M.
dc.contributor.author Silva, Simonne Almeida e
dc.contributor.author Andrade, Soraya Sgambatti [UNIFESP]
dc.contributor.author Martelli, Celina Maria Turchi
dc.date.accessioned 2016-01-24T12:33:09Z
dc.date.available 2016-01-24T12:33:09Z
dc.date.issued 2001-12-01
dc.identifier http://dx.doi.org/10.1089/10766290152773419
dc.identifier.citation Microbial Drug Resistance-mechanisms Epidemiology and Disease. Larchmont: Mary Ann Liebert Inc Publ, v. 7, n. 4, p. 403-411, 2001.
dc.identifier.issn 1076-6294
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26675
dc.description.abstract Haemophilus influenzae is a relevant cause of morbidity and mortality among children under 5 years of age in the developing world. in Latin America, H. influenzae type b (Hib) conjugate vaccine and surveillance of H. influenzae antimicrobial susceptibility have been implemented in recent years. We have undertaken a systematic review and a pooled analysis on H. influenzae antimicrobial resistance, including reports of 15 Latin America countries over a 10-year period (1990-2000). We have found that 450 (21.4%) of 2,100 invasive isolates were beta-lactamase producers compared to 145 (14.5%) of 998 isolates of noninvasive isolates (p<0.05). Ampicillin resistance was detected among 783 (21.9%) of 3,577 invasive isolates compared to 111 (17.2%) of 646 noninvasive strains (p<0.05). in contrast, 568 (41.9%) of 1,355 noninvasive strains were trimethoprimsulfamethoxazole (TMP-SMX) resistance against 241 (26.9%) of 897 invasive ones (p<0.05). Therefore, TMP-SMX resistance was more common in nonsterile fluids than in sterile fluids. Over time, rates of &beta;-lactamase-producing strains were stable in Brazil and Mexico, whereas rates of TMP-SMX resistance were increasing in Brazil. It is predictable that following the Hib immunization, Latin America countries will be faced with increased nontypeable H. influenzae infection. Although standing by the nontypeable H. influenzae vaccine, in this novel epidemiological scenario of post-Hib vaccination in Latin America settings there is a need to improve H. influenzae resistance monitoring to guide clinicians to choose efficacious antimicrobial therapy. en
dc.format.extent 403-411
dc.language.iso eng
dc.publisher Mary Ann Liebert Inc Publ
dc.relation.ispartof Microbial Drug Resistance-mechanisms Epidemiology and Disease
dc.rights Acesso restrito
dc.title Haemophilus influenzae resistance in Latin America: Systematic review of surveillance data en
dc.type Artigo
dc.contributor.institution Univ Fed Goias Brazil
dc.contributor.institution Adolfo Lutz Inst
dc.contributor.institution Pan Amer Hlth Org
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Goias Brazil, Inst Patol Trop & Saude Publ, BR-74605050 Goiania, Go, Brazil
dc.description.affiliation Adolfo Lutz Inst, São Paulo, Brazil
dc.description.affiliation Pan Amer Hlth Org, Washington, DC USA
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1089/10766290152773419
dc.description.source Web of Science
dc.identifier.wos WOS:000173401700011

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