Haemophilus influenzae resistance in Latin America: Systematic review of surveillance data

Haemophilus influenzae resistance in Latin America: Systematic review of surveillance data

Autor Andrade, Ana Lúcia Sampaio Sgambatti de Google Scholar
Brandileone, Maria Cristina Google Scholar
Di Fabio, José Luis Google Scholar
Oliveira, Renato M. Google Scholar
Silva, Simonne Almeida e Google Scholar
Andrade, Soraya Sgambatti Autor UNIFESP Google Scholar
Martelli, Celina Maria Turchi Google Scholar
Instituição Univ Fed Goias Brazil
Adolfo Lutz Inst
Pan Amer Hlth Org
Universidade Federal de São Paulo (UNIFESP)
Resumo Haemophilus influenzae is a relevant cause of morbidity and mortality among children under 5 years of age in the developing world. in Latin America, H. influenzae type b (Hib) conjugate vaccine and surveillance of H. influenzae antimicrobial susceptibility have been implemented in recent years. We have undertaken a systematic review and a pooled analysis on H. influenzae antimicrobial resistance, including reports of 15 Latin America countries over a 10-year period (1990-2000). We have found that 450 (21.4%) of 2,100 invasive isolates were beta-lactamase producers compared to 145 (14.5%) of 998 isolates of noninvasive isolates (p<0.05). Ampicillin resistance was detected among 783 (21.9%) of 3,577 invasive isolates compared to 111 (17.2%) of 646 noninvasive strains (p<0.05). in contrast, 568 (41.9%) of 1,355 noninvasive strains were trimethoprimsulfamethoxazole (TMP-SMX) resistance against 241 (26.9%) of 897 invasive ones (p<0.05). Therefore, TMP-SMX resistance was more common in nonsterile fluids than in sterile fluids. Over time, rates of &beta;-lactamase-producing strains were stable in Brazil and Mexico, whereas rates of TMP-SMX resistance were increasing in Brazil. It is predictable that following the Hib immunization, Latin America countries will be faced with increased nontypeable H. influenzae infection. Although standing by the nontypeable H. influenzae vaccine, in this novel epidemiological scenario of post-Hib vaccination in Latin America settings there is a need to improve H. influenzae resistance monitoring to guide clinicians to choose efficacious antimicrobial therapy.
Idioma Inglês
Data de publicação 2001-12-01
Publicado em Microbial Drug Resistance-mechanisms Epidemiology and Disease. Larchmont: Mary Ann Liebert Inc Publ, v. 7, n. 4, p. 403-411, 2001.
ISSN 1076-6294 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc Publ
Extensão 403-411
Fonte http://dx.doi.org/10.1089/10766290152773419
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000173401700011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26675

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