Hypothalamic involvement in chronic migraine

Hypothalamic involvement in chronic migraine

Autor Peres, Mario Fernando Prieto Autor UNIFESP Google Scholar
del Rio, M. S. Google Scholar
Seabra, MLV Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Abucham, Julio Autor UNIFESP Google Scholar
Cipolla-Neto, J. Google Scholar
Silberstein, S. D. Google Scholar
Zukerman, Eliova Autor UNIFESP Google Scholar
Instituição São Paulo Headache Ctr
Thomas Jefferson Univ Hosp
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Objectives-Chronic migraine (CM), previously called transformed migraine, is a frequent headache disorder that affects 2%-3% of the general population. Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM. Hypothalamic dysfunction has been implicated in its pathogenesis, but it has never been studied in patients with CM. the aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion.Methods-A total of 338 blood samples (13/patient) from 17 patients with CM and nine age and sex matched healthy volunteers were taken. Melatonin, prolactin, growth hormone, and cortisol concentrations were determined every hour for 12 hours. the presence of comorbid disorders was also evaluated.Results-An abnormal pattern of hypothalamic hormonal secretion was found in CM. This included: (1) a decreased nocturnal prolactin peak, (2) increased cortisol concentrations, (3) a delayed nocturnal melatonin peak in patients with CM, and (4) lower melatonin concentrations in patients with CM with insomnia. Growth hormone secretion did not differ from controls.Conclusion-These results support hypothalamic involvement in CM, shown by a chronobiologic dysregulation, and a possible hyperdopaminergic state in patients with CM. Insomnia might be an important variable in the study findings.
Palavra-chave chronic migraine
Idioma Inglês
Data de publicação 2001-12-01
Publicado em Journal of Neurology Neurosurgery and Psychiatry. London: British Med Journal Publ Group, v. 71, n. 6, p. 747-751, 2001.
ISSN 0022-3050 (Sherpa/Romeo, fator de impacto)
Publicador British Med Journal Publ Group
Extensão 747-751
Fonte http://dx.doi.org/10.1136/jnnp.71.6.747
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000172442300010
Endereço permanente http://repositorio.unifesp.br/handle/11600/26669

Exibir registro completo


Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções



Minha conta