Risk of bacterial infection in patients under intravenous iron therapy: Dose versus length of treatment

Risk of bacterial infection in patients under intravenous iron therapy: Dose versus length of treatment

Autor Canziani, MEF Google Scholar
Yumiya, S. T. Google Scholar
Rangel, E. B. Google Scholar
Manfredi, SR Google Scholar
Neto, M. C. Google Scholar
Draibe, S. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Oswaldo Ramos Fdn
Resumo Some studies have suggested that intravenous iron therapy may be associated with an increased risk of infection. We analyzed the incidence of bacterial infection in 111 hemodialysis patients. Group 1 (n = 39, transferrin saturation <20%) received 10 doses of 100 mg of intravenous iron saccharate, 3 doses per week (28 treatment days); Group 2 (n = 13, transferrin saturation <20%) received 20 doses, 3 doses per week (70 treatment days); and Group 3 (n = 59, transferrin saturation 20-50%) received 10 doses, 1 dose per week (70 treatment days). the followup was 150 days for all groups, and all infectious episodes were recorded. Pulmonary infection was the most frequent event observed in all of the groups. in an incidence-density analysis, Group 2, which received a total of 20 doses, presented a significantly higher incidence of infection than Group 3, which received only 10 doses over the same period (0.13 versus 0.06 infections per patient per month, p = 0.04). No difference was observed between Groups 1 and 2 suggesting that the risk of infection during iron therapy is dose dependent rather than time length dependent.
Assunto intravenous iron
bacterial infection
Idioma Inglês
Data 2001-11-01
Publicado em Artificial Organs. Malden: Blackwell Publishing Inc, v. 25, n. 11, p. 866-869, 2001.
ISSN 0160-564X (Sherpa/Romeo, fator de impacto)
Editor Blackwell Publishing Inc
Extensão 866-869
Fonte http://dx.doi.org/10.1046/j.1525-1594.2001.06894.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000172801600004
URI http://repositorio.unifesp.br/handle/11600/26661

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