Acute effects of low doses of melatonin on the sleep of young healthy subjects

Acute effects of low doses of melatonin on the sleep of young healthy subjects

Autor Pires, MLN Google Scholar
Benedito-Silva, A. A. Google Scholar
Pinto, L. Google Scholar
Souza, L. Google Scholar
Vismari, L. Google Scholar
Calil, H. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This study was undertaken to evaluate the acute effects of single low doses of melatonin given to healthy volunteers in the evening, Six healthy male volunteers (age range 22-24 years) participated in this study, after signing an informed consent form. They received in a double-blind fashion placebo or 0.3 or 1.0 mg melatonin at three fixed times: 18:00, 20:00, and 21:00 hr. Polysomnographic recordings began immediately thereafter, with their being allowed to sleep, Prior to each experimental session and in the following morning, subjects completed a sleep quality questionnaire, the Profile of Mood States, the Stanford Sleepiness Scale, and underwent a visual reaction test. Significant decrease on sleep latencies was found following melatonin treatment at 18:00 and 20:00 hr. in addition, melatonin tended to improve sleep efficiency and to reduce intermittent wakefulness. However, at 21:00 hr. 0.3 mg melatonin increased latency to sleep onset and 1.0 mg melatonin had no effect on sleep variables. Furthermore, melatonin given at different times did not alter subjective sleepiness, mood, and reaction time in the following morning. the results from the present study support the notion that administration of low doses of melatonin, mimicking the nocturnal physiological concentration of this hormone may exert immediate sleep-inducing effects.
Palavra-chave humans
melatonin
polysomnography
sleep
soporific
Idioma Inglês
Data de publicação 2001-11-01
Publicado em Journal of Pineal Research. Copenhagen: Munksgaard Int Publ Ltd, v. 31, n. 4, p. 326-332, 2001.
ISSN 0742-3098 (Sherpa/Romeo, fator de impacto)
Publicador Munksgaard Int Publ Ltd
Extensão 326-332
Fonte http://dx.doi.org/10.1034/j.1600-079X.2001.310407.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000172106500007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26660

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