Family-based association of HLA class II alleles and haplotypes with type I diabetes in Brazilians reveals some characteristics of a highly diversified population

Family-based association of HLA class II alleles and haplotypes with type I diabetes in Brazilians reveals some characteristics of a highly diversified population

Autor Volpini, WMG Google Scholar
Testa, G. V. Google Scholar
Marques, SBD Google Scholar
Alves, L. I. Google Scholar
Silva, MER Google Scholar
Dib, S. A. Google Scholar
Guerra, G. Google Scholar
Paulino, MFVM Google Scholar
Marini, SHVL Google Scholar
Persoli, LBL Google Scholar
Caillat-Zucman, S. Google Scholar
Instituição Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hop Necker Enfants Malad
Resumo The association of HLA class II haplotypes with type I diabetes was analyzed in 56 Southeastern Brazilian families using affected family-based controls (AFBAC) method. DRB1-DQA1-DQB1 alleles were determined by polymerase chain reaction/sequence-specific primer genotyping. This study first revealed the great haplotype diversity of Brazilians (65 different haplotypes even with incomplete DRB1 subtyping), probably due to the admixture of Africans genes with European and Amerindian genes in this population. the results revealed increased frequencies of the DRB1*03-DQA1*0501-DQB1*02 and DRB1*0401-DQA1*03-DQB1*0302 haplotypes in the patient group the highest risk for type I diabetes was associated with the heterozygote DRB1*03/*04 genotype as largely reported, and DRB1*03/X and DRB1*04/Y genotypes conferred a significant, but much lower disease risk. Protection from type I diabetes revealed some peculiarities in Southeastern Brazilians: a lack of significant protecting effect of the DRB1*1501-DQA1*0102-DQB1*0602 haplotype, and an apparent protection conferred by the DRB1*13-DQB1*0301, DRB1*11-DQB1*0301, and DRB1*01-DQB1*0501 two-locus haplotypes. the risk to type I diabetes in the highly diversified Southeastern Brazilians evidenced specific information to the prediction of the disease in this region of the country. (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.
Palavra-chave type I diabetes
HLA association
affected family-based control method
Brazilian population
Idioma Inglês
Data de publicação 2001-11-01
Publicado em Human Immunology. New York: Elsevier B.V., v. 62, n. 11, p. 1226-1233, 2001.
ISSN 0198-8859 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1226-1233
Fonte http://dx.doi.org/10.1016/S0198-8859(01)00323-8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000172014500004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26657

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