Elevation of soluble interleukin-2 receptor levels in the bronchoalveolar lavage from patients with systemic sclerosis

Elevation of soluble interleukin-2 receptor levels in the bronchoalveolar lavage from patients with systemic sclerosis

Autor Martinez, JAB Google Scholar
Nishimura, C. Google Scholar
Guatura, S. B. Google Scholar
Sato, E. Google Scholar
King, T. E. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Natl Jewish Med & Res Ctr
San Francisco Gen Hosp
Univ Calif San Francisco
Resumo This study was designed to investigate the levels of IL-2 and its soluble receptor (sIL-2R) in bronchoalveolar lavage fluid (BALF) from patients with systemic sclerosis (SSc). We studied 18 patients with SSc and 10 healthy volunteers. Based on high-resolution computed tomography lung scans the patients were divided into two groups, those with (SSc-ILD group, n=10) and those without (SSc group, n=8) evidence of interstitial lung disease (ILD). Both groups showed significantly higher total cell and neutrophil counts in the BALF than controls. the SSc group also showed significantly higher levels of lymphocytes than controls. IL-2 was not detectable in BALF. the patients showed significantly higher levels of sIL-2R than controls (77.8% vs 20%, P=0.005). the median sIL-2R levels detected did not differ between the two patient groups (SSc-ILD 270 pg/ml, SSc 232 pg/ml). This study suggests that SSc patients with or without ILD have elevated levels of sIL-2R in BALF and that in some of these patients this finding could be explained by subclinical pulmonary inflammation.
Palavra-chave soluble interleukin-2 receptor
bronchoalveolar lavage
systemic sclerosis
interstitial lung disease
Idioma Inglês
Data de publicação 2001-11-01
Publicado em Rheumatology International. New York: Springer-verlag, v. 21, n. 3, p. 122-126, 2001.
ISSN 0172-8172 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 122-126
Fonte http://dx.doi.org/10.1007/s00296-001-0147-x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000172676300008
Endereço permanente http://repositorio.unifesp.br/handle/11600/26653

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