Heteropteris aphrodisiaca O. Machado: Effects of extract BST 0298 on the oxidative stress of young and old rat brains

Heteropteris aphrodisiaca O. Machado: Effects of extract BST 0298 on the oxidative stress of young and old rat brains

Autor Mattei, R. Google Scholar
Barros, M. P. Google Scholar
Galvao, SMP Google Scholar
Bechara, EJH Google Scholar
Carlini, ELD Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo The plant Heteropteris aphrodisiaca O. Machado is widely employed in Brazilian popular medicine as a stimulant, a tonic and a remedy for nervous debility. Several other plant products with similar therapeutic applications may have such effects based on the antioxidant content of polyphenols (gallates, cathecols, etc.) and flavonoids. the aim of this work was to investigate the effects of Heteropteris aphrodisiaca O. Machado extracts on the antioxidant defences and oxidative stress of young and old rat brains. Tests of lipoperoxidation in vitro, comparing H. aphrodisiaca extracts with butylhydroxytoluene (BHT), a classic antioxidant, showed an efficient inhibition of lipoperoxidation (Q(1/2) = 3.3 mug/mL). Chronic treatment of young and old rats with 50 mg plant extract/kg body weight resulted in a significant increase in superoxide dismutase (SOD) activities (40%) in the brain of old rats, but no changes in catalase and glutathione peroxidase (GPX). No significant variations in antioxidant enzyme activities were observed in the brains of young rats. However, significantly lower levels of lipoperoxidation (30%) were detected in the brain of young rats upon plant extract administration, suggesting that H. aphrodisiaca extracts reduced the oxidative stress to brain lipids. Copyright (C) 2001 John Wiley & Sons, Ltd.
Palavra-chave Heteropteris aphrodisiaca
lipid peroxidation
oxidative stress
free radicals
aging
rat brain
Idioma Inglês
Data de publicação 2001-11-01
Publicado em Phytotherapy Research. Malden: Wiley-Blackwell, v. 15, n. 7, p. 604-607, 2001.
ISSN 0951-418X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 604-607
Fonte http://dx.doi.org/10.1002/ptr.838
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171909300009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26651

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