Immunohistochemical detection of p53 protein expression as a prognostic indicator in Wilms tumor

Show simple item record Sredni, S. T. Camargo, B. de Lopes, L. F. Teixeira, R. Simpson, A. 2016-01-24T12:31:30Z 2016-01-24T12:31:30Z 2001-11-01
dc.identifier.citation Medical and Pediatric Oncology. New York: Wiley-liss, v. 37, n. 5, p. 455-458, 2001.
dc.identifier.issn 0098-1532
dc.description.abstract Background. Mutations of the tumor suppressor gene p53 are commonly found in several kinds of human cancer. in some types of neoplasms, accumulation of p53 protein has been reported to correlate with more aggressive clinical behavior. the role of p53 expression in Wilms tumors (WT) is not clear yet, but most studies have confirmed its correlation with anaplasia and advanced stage disease. Procedure. Ninety-seven WT were evaluated for p53 expression by immunohistochemistry in formalin-fixed parafin-embedded tissue and correlated with outcome. Tumors were classified as p53-Negative (p53-N) when no positivity was observed or only few cells showed weak positivity (0/1+) and p53-Positive (p53-P) when there was a diffuse and strong nuclear positivity (2+/3). Results. p53-P was detected in 13 out of 97 tumors and was associated with disease relapse (39 vs .17%; P = 0.06) but not with anaplasia. Among p53-N patients only 5% had metastatic disease compared with 31% of the p53-P sample. (P = 0.038). Overall survival was 94% for patients with p53-N vs. 85% for patients with p53-P at 1 year (P = 0.34). Conclusions. p53 expression in Wilms tumor detected by immunohistochemistry seems to be associated with advanced disease and relapse. (C) 2001 Wiley-Liss, Inc. en
dc.format.extent 455-458
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Medical and Pediatric Oncology
dc.rights Acesso restrito
dc.subject Wilms tumors en
dc.subject pathology en
dc.subject anaplasia en
dc.subject p53 en
dc.subject prognosis en
dc.title Immunohistochemical detection of p53 protein expression as a prognostic indicator in Wilms tumor en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Canc
dc.contributor.institution Ludwig Inst Canc Res
dc.description.affiliation Hosp Canc, Dept Pediat, BR-01509000 São Paulo, Brazil
dc.description.affiliation Hosp Canc, Dept Pathol, BR-01509000 São Paulo, Brazil
dc.description.affiliation Ludwig Inst Canc Res, São Paulo Branch, São Paulo, Brazil
dc.identifier.doi 10.1002/mpo.1229
dc.description.source Web of Science
dc.identifier.wos WOS:000171981700006


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