Immunohistochemical detection of p53 protein expression as a prognostic indicator in Wilms tumor

Immunohistochemical detection of p53 protein expression as a prognostic indicator in Wilms tumor

Author Sredni, S. T. Google Scholar
Camargo, B. de Google Scholar
Lopes, L. F. Google Scholar
Teixeira, R. Google Scholar
Simpson, A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Canc
Ludwig Inst Canc Res
Abstract Background. Mutations of the tumor suppressor gene p53 are commonly found in several kinds of human cancer. in some types of neoplasms, accumulation of p53 protein has been reported to correlate with more aggressive clinical behavior. the role of p53 expression in Wilms tumors (WT) is not clear yet, but most studies have confirmed its correlation with anaplasia and advanced stage disease. Procedure. Ninety-seven WT were evaluated for p53 expression by immunohistochemistry in formalin-fixed parafin-embedded tissue and correlated with outcome. Tumors were classified as p53-Negative (p53-N) when no positivity was observed or only few cells showed weak positivity (0/1+) and p53-Positive (p53-P) when there was a diffuse and strong nuclear positivity (2+/3). Results. p53-P was detected in 13 out of 97 tumors and was associated with disease relapse (39 vs .17%; P = 0.06) but not with anaplasia. Among p53-N patients only 5% had metastatic disease compared with 31% of the p53-P sample. (P = 0.038). Overall survival was 94% for patients with p53-N vs. 85% for patients with p53-P at 1 year (P = 0.34). Conclusions. p53 expression in Wilms tumor detected by immunohistochemistry seems to be associated with advanced disease and relapse. (C) 2001 Wiley-Liss, Inc.
Keywords Wilms tumors
pathology
anaplasia
p53
prognosis
Language English
Date 2001-11-01
Published in Medical and Pediatric Oncology. New York: Wiley-liss, v. 37, n. 5, p. 455-458, 2001.
ISSN 0098-1532 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 455-458
Origin http://dx.doi.org/10.1002/mpo.1229
Access rights Closed access
Type Article
Web of Science ID WOS:000171981700006
URI http://repositorio.unifesp.br/handle/11600/26650

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