Immunohistochemical detection of p53 protein expression as a prognostic indicator in Wilms tumor

Immunohistochemical detection of p53 protein expression as a prognostic indicator in Wilms tumor

Autor Sredni, S. T. Google Scholar
Camargo, B. de Google Scholar
Lopes, L. F. Google Scholar
Teixeira, R. Google Scholar
Simpson, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Canc
Ludwig Inst Canc Res
Resumo Background. Mutations of the tumor suppressor gene p53 are commonly found in several kinds of human cancer. in some types of neoplasms, accumulation of p53 protein has been reported to correlate with more aggressive clinical behavior. the role of p53 expression in Wilms tumors (WT) is not clear yet, but most studies have confirmed its correlation with anaplasia and advanced stage disease. Procedure. Ninety-seven WT were evaluated for p53 expression by immunohistochemistry in formalin-fixed parafin-embedded tissue and correlated with outcome. Tumors were classified as p53-Negative (p53-N) when no positivity was observed or only few cells showed weak positivity (0/1+) and p53-Positive (p53-P) when there was a diffuse and strong nuclear positivity (2+/3). Results. p53-P was detected in 13 out of 97 tumors and was associated with disease relapse (39 vs .17%; P = 0.06) but not with anaplasia. Among p53-N patients only 5% had metastatic disease compared with 31% of the p53-P sample. (P = 0.038). Overall survival was 94% for patients with p53-N vs. 85% for patients with p53-P at 1 year (P = 0.34). Conclusions. p53 expression in Wilms tumor detected by immunohistochemistry seems to be associated with advanced disease and relapse. (C) 2001 Wiley-Liss, Inc.
Assunto Wilms tumors
Idioma Inglês
Data 2001-11-01
Publicado em Medical and Pediatric Oncology. New York: Wiley-liss, v. 37, n. 5, p. 455-458, 2001.
ISSN 0098-1532 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 455-458
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171981700006

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