Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette's syndrome, Sydenham's chorea, and autoimmune disorders

Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette's syndrome, Sydenham's chorea, and autoimmune disorders

Autor Morshed, S. A. Google Scholar
Parveen, S. Google Scholar
Leckman, J. F. Google Scholar
Mercadante, M. T. Google Scholar
Kiss, MHB Google Scholar
Miguel, E. C. Google Scholar
Arman, A. Google Scholar
Yazgan, Y. Google Scholar
Fujii, T. Google Scholar
Paul, S. Google Scholar
Peterson, B. S. Google Scholar
Zhang, H. P. Google Scholar
King, R. A. Google Scholar
Scahill, L. Google Scholar
Lombroso, P. J. Google Scholar
Instituição Yale Univ
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Istanbul Univ
Keio Univ
Resumo Background: Some cases of Tourette's syndrome (TS) are hypothesized to be caused by autoantibodies that develop in response to a preceding group A beta hemolytic streptococcal infection.Methods: To test this hypothesis, we looked for the presence ot total and IgG antibodies against neural, nuclear, cytoskeletal and streptococcal epitopes using indirect immunofluorescent assays and Western blot techniques in three patient groups: TS (n = 81), SC (n = 27), and a group of autoimmune disorders (n = 52) and in normal controls (n = 67). Subjects were ranked after titrations of autoantibodies from 0 to 227 according to their level of immunoreactivity.Results: TS patients had a significantly higher mean rank for total antineural and antinuclear antibodies, as well as antistreptolysin 0 titers. However, among children and adolescents, only the total antinuclear antibodies were increased in TS patients compared to age matched controls. Compared to SC patients, TS patients had a significantly lower mean rank for total and IgG class antineural antibodies, significantly lower IgG class anticytoskeletal antibodies, and a significantly higher rank for total antinuclear antibodies. Compared to a mixed group of autoimmune disorders, the TS patients had a significantly lower mean rank for total and IgG class antineural antibodies, total and IgG class antinuclear antibodies, IgG class anticytoskeletal antibodies, and a significantly higher rank for antistreptococcal antibodies.Conclusions: TS patients had significantly higher levels of total antineural and antinuclear antibodies than did controls. Their relation to IgG class antineural and antinuclear antibodies, markers for prior streptococcal infection, and other clinical characteristics, especially chronological age, was equivocal. (C) 2001 Society of Biological Psychiatry.
Assunto autoantibodies
molecular mimicry
neuropsychiatric disorders
Tourette's syndrome
Sydenham's chorea
autoimmune disorders
Idioma Inglês
Data 2001-10-15
Publicado em Biological Psychiatry. New York: Elsevier B.V., v. 50, n. 8, p. 566-577, 2001.
ISSN 0006-3223 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 566-577
Fonte http://dx.doi.org/10.1016/S0006-3223(01)01096-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171812700002
URI http://repositorio.unifesp.br/handle/11600/26643

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