Levels of specific antigen (gp43), specific antibodies, and antigen-anti body complexes in saliva and serum of paracoccidioidomycosis patients

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dc.contributor.author Miura, CSN
dc.contributor.author Estevao, D.
dc.contributor.author Lopes, Jose Daniel [UNIFESP]
dc.contributor.author Itano, E. N.
dc.date.accessioned 2016-01-24T12:31:30Z
dc.date.available 2016-01-24T12:31:30Z
dc.date.issued 2001-10-01
dc.identifier http://dx.doi.org/10.1080/mmy.39.5.423.428
dc.identifier.citation Medical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 39, n. 5, p. 423-428, 2001.
dc.identifier.issn 1369-3786
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26641
dc.description.abstract The present study analyses human immunoglobulin G (IgG) antibodies directed against the Paracoccidioides brasiliensis exoantigen, gp43, as well as the presence of gp43-IgG immune complexes (ICs) in 31 samples of saliva and serum from 19 patients with paracoccidioidomycosis (PCM) and 12 normal donors. Additional analysis of secretory IgA (sIgA) was performed on the same saliva samples. Consistent with previous findings, a significant increased specific IgG level was observed in PCM patients' saliva and serum (P<0.05). the analysis of serum gp43 and gp43-IgG IC demonstrated a higher level in patients with PCM (P<0.05); however, this difference was not statistically significant with regard to gp43 and gp43-IgG in saliva when compared to the healthy donors. A high level of sIgA in saliva of PCM patients compared to that of normal donors was also observed (P<0.05). Patients exhibiting low levels of serum IgG but with high titres of IC were observed, thus strengthening the idea of the necessity to use more than one marker for diagnosis and treatment monitoring of PCM. This is the first report of sIgA in PCM patients' saliva and may be indicative of a protective role in neutralizing antigens on mucosal surfaces. en
dc.format.extent 423-428
dc.language.iso eng
dc.publisher B I O S Scientific Publishers Ltd
dc.relation.ispartof Medical Mycology
dc.rights Acesso restrito
dc.subject gp43 en
dc.subject immune complexes en
dc.subject Paracoccidioides brasiliensis en
dc.subject paracoccidioidomycosis en
dc.title Levels of specific antigen (gp43), specific antibodies, and antigen-anti body complexes in saliva and serum of paracoccidioidomycosis patients en
dc.type Artigo
dc.contributor.institution Universidade Estadual de Londrina (UEL)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Estadual Londrina, Dept Ciencias Patol, CCB, BR-86051970 Londrina, Parana, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Immunol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Immunol, São Paulo, Brazil
dc.identifier.doi 10.1080/mmy.39.5.423.428
dc.description.source Web of Science
dc.identifier.wos WOS:000172253200007



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