Levels of specific antigen (gp43), specific antibodies, and antigen-anti body complexes in saliva and serum of paracoccidioidomycosis patients

Levels of specific antigen (gp43), specific antibodies, and antigen-anti body complexes in saliva and serum of paracoccidioidomycosis patients

Author Miura, CSN Google Scholar
Estevao, D. Google Scholar
Lopes, Jose Daniel Autor UNIFESP Google Scholar
Itano, E. N. Google Scholar
Institution Universidade Estadual de Londrina (UEL)
Universidade Federal de São Paulo (UNIFESP)
Abstract The present study analyses human immunoglobulin G (IgG) antibodies directed against the Paracoccidioides brasiliensis exoantigen, gp43, as well as the presence of gp43-IgG immune complexes (ICs) in 31 samples of saliva and serum from 19 patients with paracoccidioidomycosis (PCM) and 12 normal donors. Additional analysis of secretory IgA (sIgA) was performed on the same saliva samples. Consistent with previous findings, a significant increased specific IgG level was observed in PCM patients' saliva and serum (P<0.05). the analysis of serum gp43 and gp43-IgG IC demonstrated a higher level in patients with PCM (P<0.05); however, this difference was not statistically significant with regard to gp43 and gp43-IgG in saliva when compared to the healthy donors. A high level of sIgA in saliva of PCM patients compared to that of normal donors was also observed (P<0.05). Patients exhibiting low levels of serum IgG but with high titres of IC were observed, thus strengthening the idea of the necessity to use more than one marker for diagnosis and treatment monitoring of PCM. This is the first report of sIgA in PCM patients' saliva and may be indicative of a protective role in neutralizing antigens on mucosal surfaces.
Keywords gp43
immune complexes
Paracoccidioides brasiliensis
paracoccidioidomycosis
Language English
Date 2001-10-01
Published in Medical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 39, n. 5, p. 423-428, 2001.
ISSN 1369-3786 (Sherpa/Romeo, impact factor)
Publisher B I O S Scientific Publishers Ltd
Extent 423-428
Origin http://dx.doi.org/10.1080/mmy.39.5.423.428
Access rights Closed access
Type Article
Web of Science ID WOS:000172253200007
URI http://repositorio.unifesp.br/handle/11600/26641

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account