Levels of specific antigen (gp43), specific antibodies, and antigen-anti body complexes in saliva and serum of paracoccidioidomycosis patients

Levels of specific antigen (gp43), specific antibodies, and antigen-anti body complexes in saliva and serum of paracoccidioidomycosis patients

Autor Miura, CSN Google Scholar
Estevao, D. Google Scholar
Lopes, Jose Daniel Autor UNIFESP Google Scholar
Itano, E. N. Google Scholar
Instituição Universidade Estadual de Londrina (UEL)
Universidade Federal de São Paulo (UNIFESP)
Resumo The present study analyses human immunoglobulin G (IgG) antibodies directed against the Paracoccidioides brasiliensis exoantigen, gp43, as well as the presence of gp43-IgG immune complexes (ICs) in 31 samples of saliva and serum from 19 patients with paracoccidioidomycosis (PCM) and 12 normal donors. Additional analysis of secretory IgA (sIgA) was performed on the same saliva samples. Consistent with previous findings, a significant increased specific IgG level was observed in PCM patients' saliva and serum (P<0.05). the analysis of serum gp43 and gp43-IgG IC demonstrated a higher level in patients with PCM (P<0.05); however, this difference was not statistically significant with regard to gp43 and gp43-IgG in saliva when compared to the healthy donors. A high level of sIgA in saliva of PCM patients compared to that of normal donors was also observed (P<0.05). Patients exhibiting low levels of serum IgG but with high titres of IC were observed, thus strengthening the idea of the necessity to use more than one marker for diagnosis and treatment monitoring of PCM. This is the first report of sIgA in PCM patients' saliva and may be indicative of a protective role in neutralizing antigens on mucosal surfaces.
Palavra-chave gp43
immune complexes
Paracoccidioides brasiliensis
paracoccidioidomycosis
Idioma Inglês
Data de publicação 2001-10-01
Publicado em Medical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 39, n. 5, p. 423-428, 2001.
ISSN 1369-3786 (Sherpa/Romeo, fator de impacto)
Publicador B I O S Scientific Publishers Ltd
Extensão 423-428
Fonte http://dx.doi.org/10.1080/mmy.39.5.423.428
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000172253200007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26641

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