Choriocapillaris photodynamic therapy using indocyanine green

Choriocapillaris photodynamic therapy using indocyanine green

Autor Costa, R. A. Google Scholar
Farah, M. E. Google Scholar
Freymuller, E. Google Scholar
Morales, P. H. Google Scholar
Smith, R. Google Scholar
Cardillo, J. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo PURPOSE: To evaluate the potential of photodynamic therapy using indocyanine green for occlusion of choroidal neovascularization, the authors studied efficiency and collateral damage of photodynamic therapy-induced photothrombosis in the rabbit choriocapillary layer.METHODS: Fundus photography, fluorescein angiography, and light and transmission electron microscopy were used to study the efficiency of photodynamic therapy-induced photothrombosis using indocyanine green as the photosensitizer, and to assess the resultant collateral damage. the delivery system consisted of a modified infrared diode laser tuned to 810 nm, near the maximum absorption peak of indocyanine green.RESULTS: Choriocapillary occlusion was achieved at indocyanine green doses of 10 and 20 mg/kg and a radiant as low as 6.3 J/cm(2). When photodynamic therapy was performed with indocyanine green doses of 10 mg/kg, damage to the neural retina was minimal. Only inner photoreceptor segments showed degeneration, probably secondary to choroidal ischemia. Bruch membrane remained intact. Retinal pigment epithelium was invariably damaged, as seen with other photosensitizers. Temporary occlusion of large choroidal vessels occurred at both dye doses.CONCLUSIONS: in this experimental study, photodynamic therapy using indocyanine green and 810-nm light irradiation produced endothelium-bound intraluminal photothrombosis, with preservation of the retinal architecture and minimal loss of visual cells. Membrane targetability, hydrophilic and fluorescent properties, and activation at 805 nm suggest indocyanine green as a potential photosensitizer for choroidal neovascularization. These combined considerations point toward further study of photodynamic therapy using indocyanine green for the treatment of choroidal vascular disease. (C) 2001 by Elsevier Science Inc. All rights reserved.
Idioma Inglês
Data de publicação 2001-10-01
Publicado em American Journal of Ophthalmology. New York: Elsevier B.V., v. 132, n. 4, p. 557-565, 2001.
ISSN 0002-9394 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 557-565
Fonte http://dx.doi.org/10.1016/S0002-9394(01)01138-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171530700015
Endereço permanente http://repositorio.unifesp.br/handle/11600/26634

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