Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia

Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia

Autor Villares, J. C. Google Scholar
Stavale, J. N. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study examined the regional differences in dopamine transporter binding sites and NMDA receptor complex binding based on autoradiographic images obtained in postmortem sections of human normal brain tissues. in middle-aged control tissues, high and comparable levels of [H-3]CFT binding were observed in the caudate nucleus, putamen, and accumbens nucleus without significant alteration along the rostrocaudal axis and ventral and dorsal parts of these nuclei. in aging normal brain tissues, dopamine binding sites for [H-3]CFT were significantly reduced in the caudate nucleus, putamen, and accumbens nucleus. L-[H-3]Glutamate, [H-3]MK-801, and [H-3]glycine binding to the NMDA receptor complex was lower in aging brain tissues than in middle-aged controls. Significant correlation did occur between age and [H-3]CFT binding and between age and L-[H-3]glutamate, [H-3]MK-801, and [H-3]glycine binding sites. These results demonstrate that the basal ganglia have age-associated reductions in dopamine transporter uptake and NMDA receptors. These data support hypoactive activity of the NI MA receptor complex system with advancing age. the dopamine transporter uptake and NMDA receptors appear to be vulnerable to the aging process in the basal ganglia. (C) 2001 Academic Press.
Palavra-chave dopaminergic transporter
postmortem human brain
pallidum
L-[H-3]glutamate binding
[H-3]MK-801 binding
[H-3]glycine binding
Idioma Inglês
Data de publicação 2001-10-01
Publicado em Experimental Neurology. San Diego: Academic Press Inc, v. 171, n. 2, p. 391-404, 2001.
ISSN 0014-4886 (Sherpa/Romeo, fator de impacto)
Publicador Academic Press Inc
Extensão 391-404
Fonte http://dx.doi.org/10.1006/exnr.2001.7737
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171506100022
Endereço permanente http://repositorio.unifesp.br/handle/11600/26633

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta