The neurotensin receptor antagonist, SR48692, attenuates the expression of amphetamine-induced behavioural sensitisation in mice

The neurotensin receptor antagonist, SR48692, attenuates the expression of amphetamine-induced behavioural sensitisation in mice

Autor Costa, F. G. Google Scholar
Frussa, R. Google Scholar
Felicio, L. F. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of acute administration of the neurotensin receptor antagonist. SR48692 (2-{[1-(7-chloroquinolin-4- yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-carbonyl]amino}adamantane-2-carboxylic acid), on amphetamine-induced behavioural sensitisation were studied with the locomotor activity of mice in an open-field as an experimental parameter. the animals were repeatedly pretreated with saline or amphetamine (2.0 mg/kg, i.p. once a day, every other day for 13 days) and 2, 9 and 16 days after the last injection they received an acute i.p. administration of saline or 0.3 mg/kg SR48692 15 min before a challenge i.p. injection of 2.0 mg/kg amphetamine. Locomotor activity of the amphetamine-challenged mice was significantly higher in amphetamine-pretreated animals than in saline-pretreated mice on days 9 and 16 after withdrawal. SR48692 prevented the expression of this behavioural sensitisation. in addition. in saline-pretreated mice, the first two challenge injections of amphetamine sufficed to induce a sensitized locomotor response to the third challenge injection of the drug. SR48692 administration before amphetamine challenge injections prevented the development of this challenge injection-induced sensitisation in saline-pretreated mice but not in amphetamine-pretreated animals. in order to determine the effects of SR48692 on the expression of amphetamine-induced behavioural sensitisation in the absence of this challenge injection-induced sensitisation, the experiment was redone with a single challenge test 9 days after pretreatment, Once again, SR48692 prevented the expression of amphetamine-induced behavioural sensitisation, These results suggest that neurotensinergic transmission has a critical role in both the initiation and expression of locomotor sensitisation to amphetamine. (C) 2001 Published by Elsevier Science B.V.
Palavra-chave neurotensin
dopamine
motivation
locomotor activity
open-field
Idioma Inglês
Data de publicação 2001-09-28
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 428, n. 1, p. 97-103, 2001.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 97-103
Fonte http://dx.doi.org/10.1016/S0014-2999(01)01271-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171653600012
Endereço permanente http://repositorio.unifesp.br/handle/11600/26629

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