An enteroaggregative Escherichia coli strain of serotype O111 : H12 damages and invades cultured T84 cells and human colonic mucosa

An enteroaggregative Escherichia coli strain of serotype O111 : H12 damages and invades cultured T84 cells and human colonic mucosa

Autor Abe, Cecilia Mari Autor UNIFESP Google Scholar
Knutton, Stuart Google Scholar
Pedroso, Margareth Z. Autor UNIFESP Google Scholar
Freymuller, Edna Autor UNIFESP Google Scholar
Gomes, Tania Aparecida Tardelli Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Birmingham
Resumo The pathogenic mechanisms of enteroaggregative Escherichia coh (EAEC) are not well defined. We investigated the interaction of EAEC strain 236 (serotype O111:H12) with polarised Caco-2 and T84 human intestinal epithelia] cells lines, and,vith human jejunal and colonic mucosa. Strain 236 adhered to both polarised cell lines and to both intestinal tissue types, but caused severe damage and was invasive only in T84 cells and colonic mucosa. in contrast, prototype EAEC strain 042, which also adhered to the Cultured intestinal cell lines, did not adhere to or invade jejunal or colonic tissue. These observations suggest a heterogeneity of virulence properties within the EAEC category of diarrhoea-causing E. coli. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science BN. All rights reserved.
Palavra-chave enteroaggregative
Escherichia coli
invasion
virulence properties
adherence
Idioma Inglês
Data de publicação 2001-09-25
Publicado em Fems Microbiology Letters. Amsterdam: Elsevier B.V., v. 203, n. 2, p. 199-205, 2001.
ISSN 0378-1097 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 199-205
Fonte http://dx.doi.org/10.1111/j.1574-6968.2001.tb10841.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000171422500011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26628

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