Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3

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dc.contributor.author Meira-Lima, Ivanor Velloso [UNIFESP]
dc.contributor.author Zhao, J.
dc.contributor.author Sham, P.
dc.contributor.author Pereira, A. C.
dc.contributor.author Krieger, J. E.
dc.contributor.author Vallada, H.
dc.date.accessioned 2016-01-24T12:31:27Z
dc.date.available 2016-01-24T12:31:27Z
dc.date.issued 2001-09-01
dc.identifier http://dx.doi.org/10.1038/sj.mp.4000898
dc.identifier.citation Molecular Psychiatry. Basingstoke: Nature Publishing Group, v. 6, n. 5, p. 565-569, 2001.
dc.identifier.issn 1359-4184
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26610
dc.description.abstract Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). in addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inheritance of BPAD. the present study assesses the length of the repeats in four loci: the ERDA-1 locus which is known to account for most of the long CAG repeats detected by RED, the SEF2-1b locus which is placed in a region where positive linkage results have been reported and the loci MAB21L and KCNN3 as functional candidate genes. A Brazilian case-control sample with 115 unrelated BPAD patients and 196 healthy control subjects and 14 multiply affected bipolar families was investigated. With the case-control design the distribution of alleles between the two groups did not approach statistical significance. the extended transmission disequilibrium test (ETDT) performed in our families did not show evidence for linkage disequilibrium. Parametric and non-parametric linkage analysis also did not provide support for linkage between any of the four loci and BPAD. Our data do not support the hypothesis that variation at the polymorphic CAG/CTG repeat loci ERDA-1, SEF2-1b, MAB21L or KCNN3 influence susceptibility to BPAD in our sample. en
dc.format.extent 565-569
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Molecular Psychiatry
dc.rights Acesso aberto
dc.subject trinucleotide repeats en
dc.subject psychosis en
dc.subject genetic en
dc.subject manic-depressive illness en
dc.title Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3 en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Inst Psychiat
dc.description.affiliation Univ São Paulo, Sch Med, Inst Psychiat, Neurosci Lab LIM 27, BR-05403010 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Heart Inst InCor, Dept Med,Lab Genet & Mol Cardiol LIM 13, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Inst Psychiat, Div Psychol Med, Sect Genet Epidemiol & Biostat, London, England
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1038/sj.mp.4000898
dc.description.source Web of Science
dc.identifier.wos WOS:000170346900010



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