Allergic and immunologic parameters in patients with Fanconi's anemia

Allergic and immunologic parameters in patients with Fanconi's anemia

Autor Roxo, P. Google Scholar
Arruda, L. K. Google Scholar
Nagao, A. T. Google Scholar
Carneiro-Sampaio, MMS Google Scholar
Ferriani, VPL Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Background: Fanconi's anemia (FA) is a rare recessive chromosomal instability disorder, characterized by progressive bone marrow failure and congenital defects. Patients with FA present with recurrent infections, particularly those of the respiratory tract. Objective: the aim of the present study was to evaluate whether patients with FA have altered antibody-mediated immune responses. Methods: A group of 12 patients with FA, 5-32 years old (6 males) was studied. Serum levels of IgG, IgM, IgA and IgG subclasses, isohemagglutinin titers and specific IgG antibodies to poliovirus and measles were determined using standard methods. Immediate skin tests to common inhalant allergens were performed, and total and specific serum IgE was quantitated using a fluoroenzymatic assay (Uni-CAP, Pharmacia). Antipneumococcal antibodies were measured by ELISA before and 4-8 weeks after immunization with pneumococcal vaccine (Pneumo 23, Pasteur Merieux Connaught). Responses to serotypes 1, 3, 5, 6B, 9V and 14, which are the most prevalent in our country, were studied. Results: Ten patients had elevated IgE levels in sera, and 7 of them had detectable specific IgE and positive immediate skin tests. An inadequate response to pneumococcal vaccination was found in 2 of the 12 patients. Isohemagglutinin titers and levels of IgG, IgM, IgA and IgG subclasses and antipoliovirus and antimeasles antibodies were within the normal limits for age in all patients. Two patients had undetectable IgG4 levels (below 5 mg/dl). Conclusions: the results indicate that a proportion of patients with FA (2/12) in our study had inadequate responses to pneumococcal vaccination. No other significant abnormalities of the immune system were found in these patients. Copyright (C) 2001 S. Karger AG, Basel.
Palavra-chave Fanconi's anemia
pneumococcal polysaccharide vaccine immunoglobulin E
antibody
infections
Idioma Inglês
Data de publicação 2001-08-01
Publicado em International Archives of Allergy and Immunology. Basel: Karger, v. 125, n. 4, p. 349-355, 2001.
ISSN 1018-2438 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 349-355
Fonte http://dx.doi.org/10.1159/000053837
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171176700011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26608

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