Follow-up of patients with epidemic poststreptococcal glomerulonephritis

Follow-up of patients with epidemic poststreptococcal glomerulonephritis

Autor Pinto, SWL Google Scholar
Sesso, R. Google Scholar
Vasconcelos, E. Google Scholar
Watanabe, Y. J. Google Scholar
Pansute, A. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In 1998 there was a large outbreak of acute glomerulonephritis (GN) in Nova Serrana, Brazil, caused by group C Streptococcus zooepidemicus and linked to the consumption of contaminated cheese produced with unpasteurized milk. This study describes the follow-up of these patients after a mean of 2 years following the acute episode. of 134 patients identified in 1998, 69 patients were reexamined and underwent measurements of blood pressure, 24-hour creatinine clearance, microalbuminuria (radioimmunoassay), and urine sediment analysis. of the original group of 134 patients, 3 patients died in the acute phase and 5 patients (3.7%) required chronic dialysis. of 69 patients reevaluated, 65 patients (94%) were adults (mean age, 39 +/- 2 [SE] years) and 47 patients (68%) were women. At the follow-up examination, we found arterial hypertension in 42% of subjects (27 of 64 subjects), serum creatinine levels greater than 1.2 mg/dL in 12% (10 of 68 subjects), reduced creatinine clearance (>80 mL/min/1.73 m(2)) in 30% (20 of 67 subjects, 2 of them on chronic dialysis therapy), and increased microalbuminuria (> 20 mug/min) in 34% (22 of 65 subjects). Increased microalbuminuria and/or reduced creatinine clearance were detected in 48% of the subjects (31 of 65 subjects). Patients with microalbuminuria had greater diastolic blood pressure than those without microalbuminuria (mean, 98 +/- 4 versus 88 +/- 2 mm Hg; P = 0.02). in conclusion, after a mean of 2 years, patients with epidemic poststreptococcal GN caused by S zooepidemicus present a high rate of hypertension and frequent abnormalities of renal function, with some having reached end-stage renal disease. Longer follow-up will be important to define the prognosis of these patients. (C) 2001 by the National Kidney Foundation, Inc.
Palavra-chave poststreptococcal glomerulonephritis (PSGN)
epidemic nephritis
acute nephritis
Streptococcus zooepidemicus
follow-up
Idioma Inglês
Data de publicação 2001-08-01
Publicado em American Journal of Kidney Diseases. Philadelphia: W B Saunders Co, v. 38, n. 2, p. 249-255, 2001.
ISSN 0272-6386 (Sherpa/Romeo, fator de impacto)
Publicador W B Saunders Co
Extensão 249-255
Fonte http://dx.doi.org/10.1053/ajkd.2001.26083
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000170204700003
Endereço permanente http://repositorio.unifesp.br/handle/11600/26605

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