Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats

Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats

Autor Bellissimo, M. I. Google Scholar
Amado, D. Google Scholar
Abdalla, DSP Google Scholar
Ferreira, E. C. Google Scholar
Cavalheiro, E. A. Google Scholar
Naffah-Mazzacoratti, M. D. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo The relationship between free radical and scavenger enzymes has been found in the epileptic phenomena and reactive oxygen species have been implicated in seizure-induced neurodegeneration. Using the epilepsy model obtained by systemic administration of pilocarpine (PILO) in rats, we investigated the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as well as the hydroperoxide (HPx) concentration in the hippocampus of rats during status epilepticus (SE). silent and chronic periods. the enzyme activities as well as the HPx concentration were measured using spectrophotometric methods and the results compared to values obtained from saline-treated animals. the SOD activity decreased after long-lasting SE period and during the chronic phase. in addition, FIN levels increased in same periods whereas the GPx activity increased only in the hippocampus of animals submitted to I h of SE. Animals presenting partial seizures, those submitted to 5 h of SE and animals from the silent period (seizure free) showed normal levels of SOD, GPx and HPx. These results show a direct evidence of lipid peroxidation during seizure activity that could be responsible for neuronal damage in the hippocampus of rats, during the establishment of PILO model of epilepsy. (C) 2001 Elsevier Science B.V. All rights reserved.
Palavra-chave pilocarpine
epilepsy
superoxide dismutase
glutathione peroxidase
hydroperoxide
Idioma Inglês
Data de publicação 2001-08-01
Publicado em Epilepsy Research. Amsterdam: Elsevier B.V., v. 46, n. 2, p. 121-128, 2001.
ISSN 0920-1211 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 121-128
Fonte http://dx.doi.org/10.1016/S0920-1211(01)00269-8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000170373000004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26603

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